INT335483

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ENPP3)
Anatomy Link Frequency
basophil 2
ENPP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 34 65.12 Quite High
agonist 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 28 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease Susceptibility 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Anaphylaxis 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that the calcium-mediated signaling is essential both for the LAMP-1 CD63 and for the ENPP-3 CD203c upregulation, as A23187-mediated calcium influx stimulate both the expression of basophil activation markers and histamine release (see Figure 7), but on the same time they suggest also that the transduction pathway diverges in two distal branches, one of which (LAMP-1) is sensitive to quercetin and is related to the degranulatory event [47], the other is much more resistant to this inhibition.
Regulation (upregulation) of CD203c in basophil
1) Confidence 0.35 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.08
Our results indicate that the calcium-mediated signaling is essential both for the LAMP-1 CD63 and for the ENPP-3 CD203c upregulation, as A23187-mediated calcium influx stimulate both the expression of basophil activation markers and histamine release (see Figure 7), but on the same time they suggest also that the transduction pathway diverges in two distal branches, one of which (LAMP-1) is sensitive to quercetin and is related to the degranulatory event [47], the other is much more resistant to this inhibition.
Regulation (upregulation) of ENPP-3 in basophil
2) Confidence 0.31 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.08

General Comments

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