INT335512

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1, NFKB1) mitochondrion (NFKB1, NFKB1) cytoplasm (NFKB1, NFKB1)
cytosol (NFKB1, NFKB1) signal transduction (NFKB1, NFKB1) nucleolus (NFKB1, NFKB1)
NFKB1 (Homo sapiens)
NFKB1 (Homo sapiens)
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 20.16 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 51 82.44 Quite High
Nicotine Addiction 19 59.84 Quite High
Cancer 14 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Lung Cancer 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two studies may suggest that a lower NFkB response by the NFkB del-allele carriers after stimulation by intestinal carcinogens may lead to a lower expression of the MDR1 [21] and, thus, a lower transport activity and, eventually, an impaired defence against intestinal uptake of luminal carcinogens compared to homozygous ins-allele carriers.
NFkB Regulation (response) of NFkB Positive_regulation (lead) of Gene_expression (expression) of MDR1
1) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.31 Pain Relevance 0

General Comments

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