INT33561

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, POMC) extracellular space (Crh, POMC) extracellular region (Crh, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Crh)
Crh (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 18 92.88 High High
Fibrositis 92 84.16 Quite High
fluoxetine 3 78.36 Quite High
anesthesia 1 73.36 Quite High
Morphine 1 71.88 Quite High
agonist 3 71.84 Quite High
dexamethasone 3 52.44 Quite High
Serotonin 36 30.88 Quite Low
Neurotransmitter 11 30.48 Quite Low
substance P 24 12.96 Low Low
Disease Link Frequency Relevance Heat
Hypertension 4 98.60 Very High Very High Very High
Body Weight 1 97.32 Very High Very High Very High
Depression 18 92.88 High High
Congenital Anomalies 15 85.52 High High
Stress 61 84.28 Quite High
Fibromyalgia 92 84.16 Quite High
Frailty 1 39.20 Quite Low
Fatigue 3 8.00 Low Low
Arthralgia 1 5.12 Low Low
Pain 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the results indicate that CRH is an important mediator of the ACTH response to 5-HT.
CRH Positive_regulation (mediator) of ACTH
1) Confidence 0.45 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.28
These results indicate that the ACTH response to corticotropin releasing factor is blunted in the early stages of hypertension in SHR but later recovers.
corticotropin releasing factor Positive_regulation (response) of ACTH associated with hypertension
2) Confidence 0.32 Published 1986 Journal Hypertension Section Abstract Doc Link 3009324 Disease Relevance 0.33 Pain Relevance 0.15
Even in children with a history of sexual abuse or other abuse the data are inconsistent, with both a decreased ACTH response to exogenous CRH [13] and an increased ACTH response to exogenous CRH [14] being reported.
CRH Positive_regulation (increased) of ACTH
3) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.86 Pain Relevance 0.22

General Comments

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