INT335619

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.42
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC3R) signal transducer activity (MC3R)
Anatomy Link Frequency
MC3 4
hypothalamus 1
MC3R (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 30 98.46 Very High Very High Very High
Intracerebroventricular 65 94.20 High High
agonist 51 88.64 High High
Central nervous system 15 65.76 Quite High
Neuropeptide 15 61.68 Quite High
tolerance 5 53.76 Quite High
antagonist 5 25.28 Quite Low
ketamine 5 5.00 Very Low Very Low Very Low
Paracetamol 5 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 30 87.28 High High
Targeted Disruption 5 84.80 Quite High
Syndrome 29 58.08 Quite High
Impaired Glucose Tolerance 5 54.40 Quite High
Repression 10 52.92 Quite High
Hyperphagia 10 47.52 Quite Low
Hypoglycemia 15 23.92 Low Low
Weight Loss 5 21.20 Low Low
Body Weight 32 5.00 Very Low Very Low Very Low
Aggression 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So in vivo, an activation of the MC3/4-R could affect COUP-TFII gene expression directly through a transcriptional mechanism regardless of the peripheral effect of MTII on the other nuclei.
Positive_regulation (activation) of MC3 in MC3
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.08
In vivo, the observed induction of COUP-TFII gene expression by the fed state could be therefore mediated indirectly by insulin through the conjunction of decreasing amount of AgRP and increasing amount of POMC leading downstream to an activation of the MC3/4-R.
Positive_regulation (activation) of MC3 in MC3
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.05 Pain Relevance 0.14
These neurons are known to control food intake through the production of BDNF, a neurotrophin whose expression in the VMH is increased in response to the activation of MC3/4-R [24], [32], [33].
Positive_regulation (activation) of MC3 in MC3 associated with bdmf
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.31 Pain Relevance 0.08
As an activation of the hypothalamic MC3/4-Rs is known to induce the expression of the brain derived neurotrophic factor (BDNF) expression, a neurotrophin involved in energy homeostasis [24], [32], [33], we analyzed its expression in our different groups of mice.
Positive_regulation (activation) of MC3 in MC3 associated with bdmf
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.42
In vivo MC3/4-R activation induces COUP-TFII mRNA levels in the hypothalamus
Positive_regulation (activation) of MC3 in hypothalamus
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.27
At first glance the increased activity in both MC3R and 4R is expected to decrease food intake.
Positive_regulation (increased) of MC3R
6) Confidence 0.10 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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