INT33562

Context Info Confidence 0.36 First Reported 1986 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.61 Pain Relevance 1.20

signal transduction (Mtss1) cytoskeleton (Mtss1) cytoplasm (Mtss1)

Mtss1 (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 11 98.60 opiate 3 92.24 imagery 4 71.28 Pain 2 45.56

Disease Link Frequency Relevance Heat Medial Tibial Stress Syndrome 9 100.00 Obesity 1 87.12 Periostitis 1 51.12 Pain 2 45.56 Leg Injuries 1 36.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The use of neoprene or semi-rigid orthotics may help prevent MTSS, as evidenced by two large prospective studies.

Negative_regulation (prevent) of MTSS associated with medial tibial stress syndrome

1) Confidence 0.36 Published 2009 Journal Sports Med Section Abstract Doc Link 19530750 Disease Relevance 0.61 Pain Relevance 0.13

When the binding affinity of cystamine-dimer was compared with that of its reduced thiol-monomer, namely [D-Ala2,Leu5,cysteamine6] enkephalin, the increment in affinity was four to fivefold for both delta and mu receptors.

Negative_regulation (reduced) of thiol-monomer associated with enkephalin

2) Confidence 0.00 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 3009340 Disease Relevance 0 Pain Relevance 1.07

General Comments

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