INT335643

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
keratinocytes 1
CTSB (Homo sapiens)
PAR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 94.92 High High
c fibre 1 90.44 High High
projection neuron 2 88.76 High High
Inflammation 1 68.72 Quite High
pruritus 14 62.40 Quite High
Central nervous system 4 38.64 Quite Low
antagonist 2 27.28 Quite Low
substance P 3 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pruritus 46 97.68 Very High Very High Very High
Pain 6 94.92 High High
Skin Allergy 3 85.52 High High
INFLAMMATION 2 68.72 Quite High
Skin Diseases 1 67.68 Quite High
Disease 1 55.20 Quite High
Eczema 3 33.44 Quite Low
Chronic Renal Failure 2 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The active ingredient in cowhage has been isolated as a cysteine protease (mucunanin) that activates proteinase-activated receptor 2 (PAR2) and PAR4 [8] in nerve fibers and keratinocytes.
cysteine protease Positive_regulation (activates) of PAR4 in keratinocytes
1) Confidence 0.01 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.30 Pain Relevance 0.41

General Comments

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