INT335648

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSS) extracellular region (CTSS) lysosome (CTSS)
Anatomy Link Frequency
keratinocytes 1
CTSS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 89.76 High High
Pain 5 82.84 Quite High
c fibre 1 78.36 Quite High
projection neuron 2 76.68 Quite High
Central nervous system 4 59.68 Quite High
pruritus 14 50.32 Quite High
antagonist 2 48.32 Quite Low
substance P 3 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Allergy 3 99.36 Very High Very High Very High
Pruritus 46 98.44 Very High Very High Very High
INFLAMMATION 2 89.76 High High
Skin Diseases 1 88.72 High High
Pain 6 82.84 Quite High
Eczema 3 54.48 Quite High
Disease 1 43.12 Quite Low
Chronic Renal Failure 2 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, cathepsin S, an endogenous cysteine protease secreted by keratinocytes, was found to induce itch [10].
Localization (secreted) of cathepsin S in keratinocytes associated with pruritus
1) Confidence 0.08 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.39 Pain Relevance 0.41

General Comments

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