INT335654

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 64.16 Quite High
Pain 1 63.68 Quite High
Disease Link Frequency Relevance Heat
Thyroid Disease 5 91.68 High High
Insulin Resistance 1 85.04 High High
Obesity 2 83.44 Quite High
Hypertension 1 82.00 Quite High
Body Weight 1 66.08 Quite High
Fatigue 1 64.88 Quite High
Anxiety Disorder 2 64.52 Quite High
Depression 1 64.16 Quite High
Pain 1 63.68 Quite High
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well accepted that, in humans, most circulating T3 is derived from extrathyroidal deiodination of T4 via D2 [3]; thus, it makes sense to hypothesize that defects in D2 expression/activity could interfere with the efficacy of L-T4 monotherapy.
Negative_regulation (defects) of Gene_expression (expression) of D2
1) Confidence 0.17 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.72 Pain Relevance 0.10

General Comments

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