INT335686

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.12
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
CPA 2
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 7 67.28 Quite High
anesthesia 7 65.52 Quite High
Calcium channel 14 50.04 Quite High
Glutamate 7 18.64 Low Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 7 65.36 Quite High
American Trypanosomiasis 28 50.00 Quite Low
Cancer 7 5.00 Very Low Very Low Very Low
Togavirus Infection 7 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Wound Healing 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, evidence presented here and previous results by others suggest that the regulation of CRT retrotranslocation by calcium could be a crossroad between diverse signaling pathways.
Regulation (regulation) of Localization (retrotranslocation) of CRT
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
However, at variance with ERAD substrates and bacterial toxins, we propose that CRT retrotranslocation is modulated by structural modifications triggered by variations of ER calcium levels.
Regulation (modulated) of Localization (retrotranslocation) of CRT
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0.03
For this reason, the biological relevance of cytosolic CRT is controversial.
Regulation (controversial) of Localization (relevance) of CRT
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Calcium induced TcCRT retrotranslocation depends on its C-terminal domain
Regulation (depends) of Localization (retrotranslocation) of TcCRT
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
To evaluate whether ER calcium levels could influence TcCRT localization, we studied its variation resulting from ER calcium mobilization produced by the inhibition of the ER SERCA pump by CPA.
Regulation (influence) of Localization (localization) of TcCRT in CPA
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Here we study the effect of ER calcium concentrations on the retrotraslocation of TcCRT.


Regulation (effect) of Localization (retrotraslocation) of TcCRT
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.05 Pain Relevance 0.10
This information, combined with the several reports of cytosolic/nuclear CRT and the current knowledge about ERAD, suggests a mechanism that may regulates CRT localization within the cell.
Regulation (regulates) of Localization (localization) of CRT
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.07 Pain Relevance 0

General Comments

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