INT335719

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 94 98.48 Very High Very High Very High
chemokine 15 94.80 High High
cytokine 31 79.60 Quite High
Inflammation 2 70.16 Quite High
agonist 41 60.12 Quite High
dopamine receptor 9 50.00 Quite Low
Substantia nigra 4 40.40 Quite Low
gABA 1 32.28 Quite Low
Neurotransmitter 5 31.76 Quite Low
Somatostatin 18 28.00 Quite Low
Disease Link Frequency Relevance Heat
Adenoma 5 99.88 Very High Very High Very High
Acth-secreting Pituitary Adenoma 7 90.92 High High
Parkinson's Disease 15 73.16 Quite High
INFLAMMATION 5 70.16 Quite High
Cushing's Syndrome /

Hypercortisolism

30 51.80 Quite High
Pituitary Acth Hypersecretion 3 50.00 Quite Low
Ebola Virus Infection 2 50.00 Quite Low
Diabetes Mellitus 8 32.20 Quite Low
Hyperglycemia 2 26.72 Quite Low
Abdominal Pain 1 25.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As dopamine release is acutely impaired, synaptic concentration cannot achieve a level necessary for micromolar D2 activation.
Positive_regulation (necessary) of Gene_expression (activation) of D2 associated with dopamine
1) Confidence 0.23 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.13 Pain Relevance 0.21
Levels in D2 were higher than S2 or controls for MCP-1 and M-CSF.
Positive_regulation (higher) of Gene_expression (Levels) of D2
2) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.07 Pain Relevance 0.35
Moreover, functional studies in vitro correlated very well with the D2 expression data, and adenomas with high D2 expression responded well to either bromocriptine or the newest dopaminergic cabergoline with acute inhibition of ACTH release by 43% to 60%.


Positive_regulation (high) of Gene_expression (expression) of D2 associated with adenoma
3) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.34 Pain Relevance 0.06

General Comments

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