INT335729

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vmn1r155) cellular_component (Vmn1r155) biological_process (Vmn1r155)
Anatomy Link Frequency
muscle 2
Vmn1r155 (Mus musculus)
Vmn1r155 - R155H (3)
Pain Link Frequency Relevance Heat
imagery 9 28.32 Quite Low
Eae 15 5.20 Low Low
Hippocampus 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 100.00 Very High Very High Very High
Targeted Disruption 285 99.78 Very High Very High Very High
Apoptosis 72 99.66 Very High Very High Very High
Muscle Weakness 51 96.60 Very High Very High Very High
Muscle Disease 30 94.00 High High
Death 3 91.24 High High
Embryonic Lethality 3 89.68 High High
Brain Disease 9 83.16 Quite High
Frontotemporal Dementia 24 70.56 Quite High
Convulsion 39 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggested that mutated VCP may also cause apoptosis in mouse muscle expressing the R155H disease mutation.
Gene_expression (expressing) of R155H (R155H) in muscle associated with disease and apoptosis
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.05 Pain Relevance 0
On the other hand, transgenic mice over-expressing the most common human IBMPFD mutation, R155H, under the regulation of a muscle creatine kinase promoter demonstrated progressive muscle weakness in a dose-dependent manner starting at 6 months of age.
Gene_expression (expressing) of R155H (R155H) in muscle associated with targeted disruption and muscle weakness
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.51 Pain Relevance 0
To be able to elucidate tissue and cellular pathology of IBMPFD, we have generated a knock-in mouse model that expresses the most common VCP disease mutation R155H at endogenous level.
Gene_expression (expresses) of R155H (R155H) associated with targeted disruption and disease
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.99 Pain Relevance 0

General Comments

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