INT335730

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map1lc3b) intracellular (Map1lc3b) cytoplasm (Map1lc3b)
Anatomy Link Frequency
quadriceps 1
Muscle cells 1
Map1lc3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 15 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 285 99.62 Very High Very High Very High
Death 3 91.12 High High
Apoptosis 72 90.24 High High
Disease 81 71.52 Quite High
Muscle Disease 30 50.00 Quite Low
Pressure And Volume Under Development 6 17.16 Low Low
Muscle Weakness 51 5.00 Very Low Very Low Very Low
Convulsion 39 5.00 Very Low Very Low Very Low
Bone Disease 36 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis from knock-in VCPR155H/+ quadriceps tissue lysates demonstrated a significantly increased amount of LC3B-II when compared to the wild-type animals (Figure 5C).
Positive_regulation (increased) of LC3B-II in quadriceps associated with targeted disruption
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.75 Pain Relevance 0
Western blotting analysis demonstrated that the protein lysates extracted from the mutant cells have significantly increased amount of LC3B-II when compared to the wild-type cell lines.
Positive_regulation (increased) of LC3B-II
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.47 Pain Relevance 0
Muscle cells from the knock-in mice exhibited increased LC3B-II staining, which was concentrated in the vesicular organelles throughout the cytoplasm compared to WT (Figure 5A,B).
Positive_regulation (increased) of LC3B-II in Muscle cells associated with targeted disruption
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.65 Pain Relevance 0

General Comments

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