INT335733

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 32
Disease Relevance 28.41
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Tardbp) RNA binding (Tardbp) nucleus (Tardbp)
DNA binding (Tardbp)
Anatomy Link Frequency
brains 11
myofibrils 1
lateral 1
muscle 1
frontal cortex 1
Tardbp (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 53 82.32 Quite High
amygdala 25 77.20 Quite High
Pain 7 37.52 Quite Low
Neuritis 25 36.24 Quite Low
Neurotransmitter 7 33.20 Quite Low
Eae 60 11.12 Low Low
imagery 21 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2225 100.00 Very High Very High Very High
Dementia 171 99.84 Very High Very High Very High
Targeted Disruption 765 99.56 Very High Very High Very High
Frontotemporal Lobar Degeneration 125 99.20 Very High Very High Very High
Urological Neuroanatomy 35 99.08 Very High Very High Very High
Motor Neuron Diseases 150 98.76 Very High Very High Very High
Cognitive Disorder 117 97.00 Very High Very High Very High
Muscle Weakness 119 96.88 Very High Very High Very High
Disease 289 94.92 High High
Brain Disease 21 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
oligomers maybe the cause underlying the increase in TDP-43 levels in the 3×Tg-AD mice.
Positive_regulation (increase) of TDP-43 associated with alzheimer's dementia
1) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.88 Pain Relevance 0
The difference in TDP-43 levels between 3×Tg-AD and NonTg mice at 6 months of age might be due to a decrease in TDP-43 levels in the brains of 6-month-old 3×Tg-AD mice or to an increase in TDP-43 levels in 6-month-old NonTg mice.
Positive_regulation (increase) of TDP-43 in brains associated with alzheimer's dementia
2) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.79 Pain Relevance 0
The clinical significance of TDP-43 accumulation in AD and its relation with the two neuropathological hallmarks of AD (A?
Positive_regulation (accumulation) of TDP-43 associated with alzheimer's dementia
3) Confidence 0.60 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.93 Pain Relevance 0
The higher levels of TDP-43 and TDP-35 in 6-month-old 3×Tg-AD mice coincided with the onset of A?
Positive_regulation (levels) of TDP-43 associated with alzheimer's dementia
4) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.02 Pain Relevance 0.06
The higher levels of TDP-43 and TDP-35 in 6-month-old 3×Tg-AD mice coincided with the onset of A?
Positive_regulation (levels) of TDP-35 associated with alzheimer's dementia
5) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.02 Pain Relevance 0.06
Taken together, these data indicate that the higher levels of TDP-43 and TDP-35 in the brains of 6-month-old 3×Tg-AD mice compared to NonTg mice are due to an increase of these proteins in the 3×Tg-AD mice as a function of age and not to a decrease of the levels of TDP-43 and TDP-35 in the brains of NonTg mice.
Positive_regulation (increase) of TDP-35 in brains associated with alzheimer's dementia
6) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.85 Pain Relevance 0
oligomers accumulation on TDP-43 levels.
Positive_regulation (accumulation) of TDP-43
7) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.74 Pain Relevance 0
Taken together, these data indicate that the higher levels of TDP-43 and TDP-35 in the brains of 6-month-old 3×Tg-AD mice compared to NonTg mice are due to an increase of these proteins in the 3×Tg-AD mice as a function of age and not to a decrease of the levels of TDP-43 and TDP-35 in the brains of NonTg mice.
Positive_regulation (increase) of TDP-43 in brains associated with alzheimer's dementia
8) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.86 Pain Relevance 0
Here we show that levels of TDP-43 and its ~35 kDa C-terminal fragment are significantly increased in the 3×Tg-AD mice, an animal model of AD that develops an age-dependent cognitive decline linked to the accumulation of A?
Positive_regulation (increased) of TDP-43 associated with cognitive disorder and alzheimer's dementia
9) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2989316 Disease Relevance 0.97 Pain Relevance 0
The accumulation of TDP-43 has been linked to FTLD-U and ALS [29].
Positive_regulation (accumulation) of TDP-43 associated with frontotemporal lobar degeneration and motor neuron diseases
10) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.82 Pain Relevance 0.08
oligomers and the increase in TDP-43 levels.


Positive_regulation (increase) of TDP-43
11) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.78 Pain Relevance 0
accumulation on TDP-43, we measured the steady-state levels of TDP-43 and TDP-35 in the low salt fraction of proteins extracted from the brains of the APP/tau mice by Western blot (Figure 6D).
Positive_regulation (accumulation) of TDP-43 in brains
12) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.58 Pain Relevance 0
oligomers levels in the 3×Tg-AD mice peak at 6 months of age and are significantly lower at 12 months of age [44], which is consistent with the hypothesis that the increased TDP-43 levels in 6-month-old 3×Tg-AD mice may be due to high levels of A?
Positive_regulation (increased) of TDP-43 associated with alzheimer's dementia
13) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.96 Pain Relevance 0
In contrast, the brains of 6-month-old 3×Tg-AD mice had significantly higher levels of TDP-43 and TDP-35 than the age- and gender-matched NonTg mice (Figure 1C-D).
Positive_regulation (levels) of TDP-43 in brains associated with alzheimer's dementia
14) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.16 Pain Relevance 0.07
Recently, TDP-43 has been found to be the main protein that accumulates in frontotemporal lobar degeneration with ubiquitin positive inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS) [29].
Positive_regulation (accumulates) of TDP-43 in lateral associated with dementia, frontotemporal lobar degeneration and motor neuron diseases
15) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.89 Pain Relevance 0
accumulation on TDP-43, we measured the steady-state levels of TDP-43 and TDP-35 in the low salt fraction of proteins extracted from the brains of the APP/tau mice by Western blot (Figure 6D).
Positive_regulation (accumulation) of TDP-35 in brains
16) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.58 Pain Relevance 0
accumulation on TDP-43, we measured the steady-state levels of TDP-43 and TDP-35 in the low salt fraction of proteins extracted from the brains of the APP/tau mice by Western blot (Figure 6D).
Positive_regulation (accumulation) of TDP-43 in brains
17) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.58 Pain Relevance 0
oligomers may be responsible for the increase in the steady-state levels of TDP-43 and TDP-35.
Positive_regulation (increase) of TDP-35
18) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.83 Pain Relevance 0
oligomers may be responsible for the increase in the steady-state levels of TDP-43 and TDP-35.
Positive_regulation (increase) of TDP-43
19) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.82 Pain Relevance 0
42 production restores the levels of TDP-43 and its ~35 kDa C-terminal fragment to control levels.


Positive_regulation (restores) of TDP-43
20) Confidence 0.47 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2989316 Disease Relevance 0.86 Pain Relevance 0

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