INT33579

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Context Info
Confidence 0.33
First Reported 1986
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 17
Disease Relevance 5.09
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Enpep) peptidase activity (Enpep) plasma membrane (Enpep)
Anatomy Link Frequency
vas deferens 1
kidney 1
Enpep (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 14 98.36 Very High Very High Very High
Enkephalin 4 91.80 High High
agonist 28 72.76 Quite High
antagonist 70 69.04 Quite High
bradykinin 2 53.04 Quite High
Pain 2 43.16 Quite Low
depression 14 42.00 Quite Low
Central nervous system 4 41.96 Quite Low
Cholecystokinin 2 38.68 Quite Low
Dismenorea 28 29.20 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 382 98.72 Very High Very High Very High
Pre-eclampsia 644 96.56 Very High Very High Very High
Stress 42 93.76 High High
Pre-term Labor 378 92.92 High High
Birth Weight 14 82.16 Quite High
Snake Bites 24 82.08 Quite High
Disease 28 79.56 Quite High
Premature Birth 84 72.52 Quite High
Targeted Disruption 28 67.60 Quite High
Hypoxia 28 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Positive_regulation (increased) of APA associated with pre-eclampsia
1) Confidence 0.33 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.10
APA activity was upregulated during AngII-induced cell proliferation; thus, it appears that increased levels of either AngII or APA result in a compensatory response, presumably representing an attempt to maintain homeostasis.
Positive_regulation (upregulated) of APA
2) Confidence 0.33 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.05
Treatment with both E and P showed a tendency to increase APA activity, but this effect was not statistically significant compared with control (olive oil).
Positive_regulation (increase) of APA
3) Confidence 0.33 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.21 Pain Relevance 0
However, APA activity in the kidney was significantly increased by E accompanied with P (Figure 6, unpublished data).
Positive_regulation (increased) of APA in kidney
4) Confidence 0.29 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.23 Pain Relevance 0
However, AngII levels in high-salt DSS rats at week 10 did not change despite increased APA activity.
Positive_regulation (increased) of APA
5) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.42 Pain Relevance 0
APA activity was upregulated during AngII-induced cell proliferation; thus, it appears that increased levels of either AngII or APA result in a compensatory response, presumably representing an attempt to maintain homeostasis.
Positive_regulation (increased) of APA
6) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.05
Our laboratory has also shown that APA activity increased with the addition of AngII to a primary culture of normal placental trophoblasts [63].
Positive_regulation (increased) of APA
7) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.04
However, the data in both previous and present studies showed that the activity of the bestatin-sensitive aminopeptidase relative to that of either the captopril-sensitive peptidyl dipeptidase A or the thiorphan-sensitive endopeptidase-24.11 in guinea pig ileum was higher than that in mouse vas deferens, while the activity of either peptidyl dipeptidase A or endopeptidase-24.11 relative to that of aminopeptidase in mouse vas deferens was higher than that in guinea-pig ileum.
Positive_regulation (higher) of aminopeptidase in vas deferens
8) Confidence 0.23 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3009948 Disease Relevance 0 Pain Relevance 0.31
Renal APA activity is elevated 3-fold at week 10 in high-salt DSR rats, similar to that seen in high-salt DSS rats.
Positive_regulation (elevated) of APA
9) Confidence 0.22 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.37 Pain Relevance 0
We have shown that progesterone, and probably estrogen, increases APA levels in human trophoblastic cells.
Positive_regulation (increases) of APA
10) Confidence 0.22 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.59 Pain Relevance 0
This increase in renal APA may serve to metabolize AngII, thus protecting the high-salt DSR rat from hypertension in response to high salt intake.
Positive_regulation (increase) of APA associated with hypertension
11) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.36 Pain Relevance 0
Aminopeptidases such as placental leucine aminopeptidase (P-LAP) and aminopeptidase A (APA) are large molecules that do not cross the placental barrier.
Positive_regulation (placental) of aminopeptidase
12) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3005972 Disease Relevance 0.61 Pain Relevance 0
This increase in renal APA at week 10 may serve to degrade AngII and temporarily protect this model.
Positive_regulation (increase) of APA
13) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.30 Pain Relevance 0
Aminopeptidases such as placental leucine aminopeptidase (P-LAP) and aminopeptidase A (APA) are large molecules that do not cross the placental barrier.
Positive_regulation (leucine) of aminopeptidase
14) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3005972 Disease Relevance 0.61 Pain Relevance 0
The baseline systolic BP (SBP) is significantly elevated in APA?
Positive_regulation (elevated) of APA
15) Confidence 0.19 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.54 Pain Relevance 0
The diversity and relatively high levels of aminopeptidase in snake venoms offer a valuable source of protein for characterisation of this complex family of enzymes.
Positive_regulation (levels) of aminopeptidase
16) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0.22 Pain Relevance 0.03
This confirms that the Glu-AMC activity of the purified rhiminopeptidase A is due to the activity of an aminopeptidase A and is not caused by any other enzyme.
Neg (not) Positive_regulation (caused) of aminopeptidase
17) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0

General Comments

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