INT335864

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.36
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sost) extracellular region (Sost) Golgi apparatus (Sost)
transcription factor binding (Sost)
Anatomy Link Frequency
osteoblast 1
parathyroid 1
Sost (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 3 96.36 Very High Very High Very High
Pain 3 88.48 High High
antagonist 9 81.44 Quite High
midbrain 3 51.96 Quite High
agonist 3 39.72 Quite Low
Serotonin 21 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 48 99.98 Very High Very High Very High
Disease 27 98.32 Very High Very High Very High
Osteoarthritis 3 96.36 Very High Very High Very High
Multiple Myeloma 3 95.60 Very High Very High Very High
Congenital Anomalies 12 89.36 High High
Pain 3 88.48 High High
Hypercalcemia 12 87.48 High High
Cancer 12 79.60 Quite High
Targeted Disruption 9 74.96 Quite High
Conductive Hearing Loss 3 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have reported that sclerostin gene expression and protein levels are reduced in animals treated with daily injections of human parathyroid hormone (hPTH) (1–34).
Gene_expression (expression) of sclerostin gene in parathyroid
1) Confidence 0.77 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.44 Pain Relevance 0
A deletion downstream of the SOST gene, which results in reduced sclerostin expression, is associated with a milder form of the disease called van Buchem disease [5].
Gene_expression (expression) of sclerostin associated with disease
2) Confidence 0.77 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.20 Pain Relevance 0
Serum sclerostin levels are significantly higher in postmenopausal women than in premenopausal women with significant negative correlations between free estrogen levels and sclerostin as well as PTh and sclerostin [8].
Gene_expression (levels) of sclerostin
3) Confidence 0.67 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.19 Pain Relevance 0
Additional work suggests that this deletion results in downregulation of Sost expression [65–67].
Gene_expression (expression) of Sost
4) Confidence 0.55 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.43 Pain Relevance 0.04
Thus, Lrp4 is also an osteoblast-expressed Dkk1- and sclerostin-receptor with a physiological role in the regulation of bone growth and turnover.
Gene_expression (expressed) of sclerostin in osteoblast associated with osteoporosis
5) Confidence 0.55 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.53 Pain Relevance 0.09
Secreted frizzled related proteins are similar to DKK1 and Sclerostin in that they also inhibit Wnt/?
Gene_expression (similar) of Sclerostin
6) Confidence 0.55 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.57 Pain Relevance 0.07

General Comments

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