INT335865

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Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.46
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Lrp6) plasma membrane (Lrp6)
Anatomy Link Frequency
tail 2
Lrp6 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 3 95.04 Very High Very High Very High
antagonist 9 50.00 Quite Low
Osteoarthritis 3 17.28 Low Low
Serotonin 21 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 30 84.92 Quite High
Congenital Anomalies 12 84.48 Quite High
Bone Cancer 18 81.36 Quite High
Cervical Cancer 3 62.32 Quite High
Stomach Cancer 3 58.92 Quite High
Syndactyly 6 40.48 Quite Low
Craniofacial Abnormalities 3 35.60 Quite Low
Cancer 12 19.00 Low Low
Familial Adenomatous Polyposis 3 18.76 Low Low
Osteoarthritis 3 17.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently shown that Lrp6 physically interacts with Wnt5a, but that this does not lead to phosphorylation of Lrp6 or activation of the Wnt/?
Neg (not) Positive_regulation (lead) of Phosphorylation (phosphorylation) of Lrp6
1) Confidence 0.64 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.08 Pain Relevance 0
The subsequent acidification of this compartment is required for phosphorylation of the cytoplasmic tail of LRP6, which is necessary for activating the downstream signaling cascade [106–108].
Positive_regulation (required) of Phosphorylation (phosphorylation) of LRP6 in tail
2) Confidence 0.64 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.29 Pain Relevance 0.05
It was recently shown that Lrp6 physically interacts with Wnt5a, but that this does not lead to phosphorylation of Lrp6 or activation of the Wnt/?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Lrp6
3) Confidence 0.46 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.08 Pain Relevance 0

General Comments

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