INT335868

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sost) extracellular region (Sost) Golgi apparatus (Sost)
transcription factor binding (Sost)
Anatomy Link Frequency
parathyroid 2
Sost (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 82.16 Quite High
agonist 1 40.44 Quite Low
Pain 1 15.36 Low Low
Serotonin 7 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
spinal stenosis 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 11 98.32 Very High Very High Very High
Congenital Anomalies 4 89.36 High High
Hypercalcemia 8 87.48 High High
Targeted Disruption 6 74.96 Quite High
Conductive Hearing Loss 1 71.00 Quite High
Facial Paralysis 1 69.88 Quite High
Fracture Healing 15 64.84 Quite High
Osteoporosis 22 64.00 Quite High
Syndactyly 2 62.60 Quite High
Cancer 4 19.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A deletion downstream of the SOST gene, which results in reduced sclerostin expression, is associated with a milder form of the disease called van Buchem disease [5].
Negative_regulation (reduced) of Gene_expression (expression) of sclerostin associated with disease
1) Confidence 0.58 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.20 Pain Relevance 0
Several studies have reported that sclerostin gene expression and protein levels are reduced in animals treated with daily injections of human parathyroid hormone (hPTH) (1–34).
Negative_regulation (reduced) of Gene_expression (expression) of sclerostin gene in parathyroid
2) Confidence 0.58 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.49 Pain Relevance 0
Additional work suggests that this deletion results in downregulation of Sost expression [65–67].
Negative_regulation (downregulation) of Gene_expression (expression) of Sost
3) Confidence 0.42 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.43 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox