INT335869

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.79
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sost) extracellular region (Sost) Golgi apparatus (Sost)
transcription factor binding (Sost)
Anatomy Link Frequency
osteocytes 1
femur 1
Sost (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 35 82.32 Quite High
Pain 5 67.44 Quite High
antagonist 15 59.92 Quite High
agonist 5 18.20 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 15 92.40 High High
Retina Disease 5 89.80 High High
Osteoporosis 56 88.96 High High
Disease 37 88.80 High High
Bone Cancer 30 85.92 High High
Congenital Anomalies 20 84.92 Quite High
Pain 5 67.44 Quite High
Cancer 20 58.56 Quite High
Conductive Hearing Loss 5 48.76 Quite Low
Facial Paralysis 5 47.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sclerostin after secretion by osteocytes travels through osteocyte canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 thus preventing colocalization with frizzled protein and Wnt signaling, and thereby reducing osteoblastogenesis and bone formation [3].
Sclerostin Binding (travels) of in osteocytes
1) Confidence 0.32 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.12 Pain Relevance 0
These mutations were either in the gene encoding the low density lipoprotein receptor-related protein-5 (LRP5) or in a gene (SOST) encoding a protein (Sclerostin) that potentially binds and regulates the function of LRP5 and its family members LRP4 and LRP6.
SOST Binding (binds) of
2) Confidence 0.30 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.17 Pain Relevance 0.04
These mutations were either in the gene encoding the low density lipoprotein receptor-related protein-5 (LRP5) or in a gene (SOST) encoding a protein (Sclerostin) that potentially binds and regulates the function of LRP5 and its family members LRP4 and LRP6.
Sclerostin Binding (binds) of
3) Confidence 0.30 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.17 Pain Relevance 0.04
Consistent with the skeletal overgrowth seen in patients carrying the G171V mutation in LRP5, Sost is unable to interact with the mutated version of LRP5 [70, 71].
Sost Neg (unable) Binding (interact) of
4) Confidence 0.29 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.24 Pain Relevance 0.03
In addition, it has recently been shown that LRP4, which is expressed in bone and cultured osteoblasts, binds Dkk1 and sclerostin in vitro and that Lrp4-deficient mice revealed shortened total femur length, reduced cortical femoral perimeter, reduced total femur bone mineral content (BMC), and bone mineral density (BMD) [58].
sclerostin Binding (binds) of in femur
5) Confidence 0.25 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.54 Pain Relevance 0.07
The LRP5-G171V protein can no longer be bound by several proteins (such as Dkk1, Sost, and MESD) that may normally regulate its activity.
Sost Neg (no) Binding (bound) of
6) Confidence 0.25 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.56 Pain Relevance 0

General Comments

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