INT335875

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Lrp6) plasma membrane (Lrp6)
Anatomy Link Frequency
Parathyroid 1
Lrp6 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 21 98.14 Very High Very High Very High
adenocard 3 71.04 Quite High
antagonist 9 50.00 Quite Low
cINOD 6 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 30 91.20 High High
Craniofacial Abnormalities 3 82.20 Quite High
Syndactyly 6 79.28 Quite High
Bone Cancer 18 57.36 Quite High
Congenital Anomalies 12 57.24 Quite High
Cervical Cancer 3 38.32 Quite Low
Stomach Cancer 3 34.92 Quite Low
Cancer 12 28.24 Quite Low
Disease 21 5.00 Very Low Very Low Very Low
Fracture Healing 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the anabolic actions of Parathyroid hormone (the basis for Forteo/teriparatide [109]) have been proposed to directly and/or indirectly work through regulation of LRP6 and/or LRP5 signaling [110–112].
Regulation (regulation) of LRP6 in Parathyroid
1) Confidence 0.57 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.21 Pain Relevance 0.04
While not discounting the potential importance of serotonin-based therapies, this paper primarily focuses on the development of agents that potentially target LRP5, and the related proteins LRP6 and LRP4, in the bone itself.

2.

Regulation (target) of LRP6 associated with serotonin
2) Confidence 0.42 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.23
In addition, changes in both LRP5 and LRP6 have been linked to alterations in glucose homeostasis and lipid metabolism [38–43], although it is not certain whether these latter functions are dependent on the Wnt/?
Regulation (changes) of LRP6
3) Confidence 0.42 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.22 Pain Relevance 0

General Comments

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