INT335878

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sost) extracellular region (Sost) Golgi apparatus (Sost)
transcription factor binding (Sost)
Anatomy Link Frequency
DAN 2
osteocytes 1
Sost (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 96.44 Very High Very High Very High
agonist 2 63.92 Quite High
Pain 2 38.84 Quite Low
Serotonin 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Conductive Hearing Loss 2 94.48 High High
Facial Paralysis 2 93.36 High High
Disease 16 86.64 High High
Syndactyly 4 86.08 High High
Congenital Anomalies 8 61.84 Quite High
Cancer 8 43.36 Quite Low
Pain 2 38.84 Quite Low
Osteoporosis 26 31.68 Quite Low
Fracture Healing 15 5.00 Very Low Very Low Very Low
Bone Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sclerostin after secretion by osteocytes travels through osteocyte canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 thus preventing colocalization with frizzled protein and Wnt signaling, and thereby reducing osteoblastogenesis and bone formation [3].
Localization (secretion) of Sclerostin in osteocytes
1) Confidence 0.69 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.11 Pain Relevance 0
This gene which encodes a secreted glycoprotein (Sclerostin or Sost) containing a cysteine knot-like domain with homology to the Cerebrus/DAN family of BMP antagonists [63, 64].
Localization (secreted) of Sclerostin in DAN associated with antagonist
2) Confidence 0.57 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.50 Pain Relevance 0.11
This gene which encodes a secreted glycoprotein (Sclerostin or Sost) containing a cysteine knot-like domain with homology to the Cerebrus/DAN family of BMP antagonists [63, 64].
Localization (secreted) of Sost in DAN associated with antagonist
3) Confidence 0.57 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.50 Pain Relevance 0.11

General Comments

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