INT335883

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0

plasma membrane (Lrp6, Wnt5a) cell differentiation (Wnt5a) endoplasmic reticulum (Lrp6) embryo development (Wnt5a) cell-cell signaling (Wnt5a) cytoplasm (Wnt5a)

Lrp6 (Mus musculus) Wnt5a (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 3 50.00 Serotonin 7 5.00 cINOD 2 5.00 midbrain 1 5.00 adenocard 1 5.00 Inflammatory response 1 5.00 Pain 1 5.00 agonist 1 5.00 Osteoarthritis 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 4 78.88 Osteoporosis 10 44.36 Syndactyly 2 34.88 Craniofacial Abnormalities 1 30.00 Cancer 4 21.44 Familial Adenomatous Polyposis 1 21.20 Disease 7 5.00 Bone Cancer 6 5.00 Fracture Healing 5 5.00 Syndrome 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was recently shown that Lrp6 physically interacts with Wnt5a, but that this does not lead to phosphorylation of Lrp6 or activation of the Wnt/?

Lrp6 Binding (interacts) of Wnt5a

1) Confidence 0.27 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.