INT335890

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dkk1, Lrp4) anatomical structure development (Lrp4) extracellular space (Dkk1)
extracellular region (Dkk1)
Anatomy Link Frequency
femur 1
Dkk1 (Mus musculus)
Lrp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 66.24 Quite High
antagonist 3 50.00 Quite Low
agonist 1 16.40 Low Low
Serotonin 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 7 91.16 High High
Osteoporosis 10 81.04 Quite High
Syndrome 3 68.04 Quite High
Pain 1 66.24 Quite High
Retina Disease 1 65.44 Quite High
Cancer 4 57.36 Quite High
Congenital Anomalies 4 20.80 Low Low
Bone Cancer 6 5.00 Very Low Very Low Very Low
Fracture Healing 5 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has recently been shown that LRP4, which is expressed in bone and cultured osteoblasts, binds Dkk1 and sclerostin in vitro and that Lrp4-deficient mice revealed shortened total femur length, reduced cortical femoral perimeter, reduced total femur bone mineral content (BMC), and bone mineral density (BMD) [58].
Dkk1 Binding (binds) of LRP4 in femur
1) Confidence 0.37 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.64 Pain Relevance 0.07

General Comments

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