INT3359

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Context Info
Confidence 0.60
First Reported 1978
Last Reported 2009
Negated 6
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 8.19
Pain Relevance 19.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
SH-SY5Y 5
neuronal 1
proximal 1
embryonic kidney 1
heart 1
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 52 100.00 Very High Very High Very High
Opioid 25 100.00 Very High Very High Very High
opiate 14 100.00 Very High Very High Very High
Delta opioid receptors 6 100.00 Very High Very High Very High
orphanin 3 100.00 Very High Very High Very High
Cannabinoid 2 100.00 Very High Very High Very High
Morphine 40 99.92 Very High Very High Very High
opioid receptor 22 99.92 Very High Very High Very High
Enkephalin 33 99.80 Very High Very High Very High
methadone 12 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 1 99.48 Very High Very High Very High
Pain 228 99.40 Very High Very High Very High
Neuroblastoma 8 99.22 Very High Very High Very High
Neuropathic Pain 1 99.00 Very High Very High Very High
Appetite Loss 1 98.70 Very High Very High Very High
Ganglion Cysts 5 98.44 Very High Very High Very High
Cv General 3 Under Development 1 98.40 Very High Very High Very High
INFLAMMATION 3 98.16 Very High Very High Very High
Tics 3 98.04 Very High Very High Very High
Stress 3 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we explored the relationship between ligand-induced regulation of surface delta opioid receptors and G protein activation.
Regulation (regulation) of delta associated with delta opioid receptors
1) Confidence 0.60 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11504798 Disease Relevance 0.20 Pain Relevance 0.29
This differential regulation of the delta receptor may be due to variations in the ability of agonists to bind to the receptor.
Regulation (regulation) of delta associated with agonist
2) Confidence 0.60 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9271350 Disease Relevance 0 Pain Relevance 1.46
The data confirm the importance of Tic for delta affinity and antagonism, while heterocyclic or heteroaliphatic nuclei, or spacer exert effects on mu- and delta-receptor properties.
Regulation (effects) of delta associated with tics
3) Confidence 0.44 Published 2000 Journal Peptides Section Abstract Doc Link 11090920 Disease Relevance 0.26 Pain Relevance 0.17
Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN).
Regulation (found) of delta associated with appetite loss, neurotransmitter, opioid, serotonin and eating disorder
4) Confidence 0.44 Published 2003 Journal Mol. Psychiatry Section Abstract Doc Link 12740597 Disease Relevance 0.69 Pain Relevance 0.27
The influence of stereochemistry as well as the substitution pattern of the phenyl-ring in position 1 on the affinity for the orphanin FQ receptor and selectivity to opioid (mu, kappa, delta) receptors is discussed.
Regulation (influence) of delta associated with orphanin and opioid
5) Confidence 0.44 Published 1999 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 10476866 Disease Relevance 0 Pain Relevance 0.37
Different regulation of human delta-opioid receptors by SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and endogenous enkephalins.
Regulation (regulation) of delta associated with enkephalin and delta opioid receptors
6) Confidence 0.44 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.92
Changes in oxyhemoglobin (Delta cO2Hb) and deoxyhemoglobin (Delta cHHb) were assessed using near infrared spectrophotometry.
Regulation (Changes) of Delta
7) Confidence 0.44 Published 2006 Journal Biol. Neonate Section Body Doc Link 16717443 Disease Relevance 0.08 Pain Relevance 0
The actions of trimebutine [3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutylester] on the gastrointestinal tract are mediated via (i) an agonist effect on peripheral mu, kappa and delta opiate receptors and (ii) release of gastrointestinal peptides such as motilin and modulation of the release of other peptides, including vasoactive intestinal peptide, gastrin and glucagon.
Regulation (effect) of delta associated with agonist and opiate
8) Confidence 0.44 Published 1997 Journal J. Int. Med. Res. Section Abstract Doc Link 9364286 Disease Relevance 0.05 Pain Relevance 0.20
Differential effects of impaired mitochondrial energy production on the function of mu and delta opioid receptors in neuronal SK-N-SH cells.
Regulation (effects) of delta in neuronal associated with delta opioid receptors
9) Confidence 0.44 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16808998 Disease Relevance 0.38 Pain Relevance 0.65
Effect of certain anaesthetic agents on the activity of rat hepatic delta-aminolaevulinate synthase.
Regulation (Effect) of delta
10) Confidence 0.44 Published 1978 Journal Br J Anaesth Section Title Doc Link 718778 Disease Relevance 0 Pain Relevance 0.31
Neither undifferentiated SH-SY5Y cells nor NG108-15 mouse neuroblastoma x rat glioma hybrid cells (expressing delta-receptors) were affected by rHu-IFN-alpha 2A.
Neg (nor) Regulation (affected) of delta in SH-SY5Y associated with neuroblastoma and glioma
11) Confidence 0.44 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003770 Disease Relevance 0.28 Pain Relevance 0.23
D-Ala-D-Leu-enkephalin binding revealed a 26% decrease in the number but no change in the affinity of delta-opiate receptors in the striata of IDPN-treated rats.
Neg (no) Regulation (change) of delta associated with opiate and enkephalin
12) Confidence 0.44 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3027623 Disease Relevance 0.45 Pain Relevance 0.27
Affinities of these fluorinated peptides for both mu- and delta- opioid receptors are reduced (two- to nine-fold) relative to their nonfluorinated analogues, but their selectivity for mu-opioid receptors is not significantly altered.
Regulation (Affinities) of delta associated with mu opioid receptor and opioid receptor
13) Confidence 0.44 Published 1991 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1680830 Disease Relevance 0 Pain Relevance 0.21
The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes.
Regulation (role) of YY1 in proximal associated with mu opioid receptor
14) Confidence 0.41 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.35
These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells.
Neg (not) Regulation (alter) of YY1 in SH-SY5Y
15) Confidence 0.40 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243600 Disease Relevance 0.19 Pain Relevance 0.44
These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells.
Neg (not) Regulation (alter) of YY1 in SH-SY5Y
16) Confidence 0.40 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243600 Disease Relevance 0.19 Pain Relevance 0.42
In humans, controlled clinical trials with Delta-tetrahydrocannabinol or other cannabinoids demonstrated analgesic efficacy in chronic pain syndromes, whereas the data in acute pain were less conclusive.
Regulation (controlled) of Delta-tetrahydrocannabinol associated with syndrome, acute pain, lasting pain, analgesic and cannabinoid
17) Confidence 0.39 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18580179 Disease Relevance 0.64 Pain Relevance 1.10
Treatment with DAMGO or deltorphin II led to coregulated internalization of both receptors, whereas DPDPE and DSLET had no effect on mu-delta internalization.
Neg (no) Regulation (effect) of delta
18) Confidence 0.26 Published 2007 Journal Biochemistry Section Abstract Doc Link 17941650 Disease Relevance 0 Pain Relevance 0.30
RESULTS: Within this pilot-study, the profile revealed a small-fiber sensory neuropathy selectively affecting C- and A-delta fibers.
Regulation (affecting) of delta
19) Confidence 0.26 Published 2008 Journal Pain Med Section Body Doc Link 18565003 Disease Relevance 0.08 Pain Relevance 0
Our results suggest a possible participation of the alpha 2/delta subunit in the action of GBP.
Spec (possible) Regulation (participation) of delta associated with gabapentin
20) Confidence 0.26 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303064 Disease Relevance 0.40 Pain Relevance 0.90

General Comments

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