INT33591

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Context Info
Confidence 0.32
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.42
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
hypothalamus 2
plasma 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 5 99.88 Very High Very High Very High
antidepressant 1 99.14 Very High Very High Very High
noradrenaline 16 98.80 Very High Very High Very High
Deafferentation 3 98.46 Very High Very High Very High
Opioid 4 96.40 Very High Very High Very High
Inflammation 81 90.36 High High
antagonist 119 90.08 High High
cytokine 66 87.72 High High
Hippocampus 39 83.44 Quite High
Morphine 2 83.40 Quite High
Disease Link Frequency Relevance Heat
Stress 258 100.00 Very High Very High Very High
Targeted Disruption 66 99.84 Very High Very High Very High
Anxiety Disorder 11 96.64 Very High Very High Very High
INFLAMMATION 84 90.36 High High
Cytomegalovirus Infection 3 77.72 Quite High
Post-traumatic Stress Disorder 27 74.32 Quite High
Hyperplasia 18 68.76 Quite High
Depression 8 59.00 Quite High
Apoptosis 5 47.44 Quite Low
Neurodegenerative Disease 2 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone also attenuated the exaggeration in stress-induced HPA activity but did not affect the increases in plasma ACTH concentration which followed adrenalectomy.
Negative_regulation (attenuated) of Neg (not) Positive_regulation (induced) of HPA in plasma associated with stress and narcan
1) Confidence 0.32 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3010154 Disease Relevance 0.29 Pain Relevance 0.33
Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.
Negative_regulation (decrease) of Positive_regulation (induced) of HPA associated with stress and antidepressant
2) Confidence 0.14 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.11 Pain Relevance 0.18
It has recently been proposed that pregnancy-related reduction in HPA activation is due to suppression of PVN noradrenaline (NA) release caused by increased pre-synaptic opioid inhibition (Brunton et al., 2008; Russell et al., 2008).
Negative_regulation (reduction) of Positive_regulation (activation) of HPA associated with noradrenaline and opioid
3) Confidence 0.12 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.30 Pain Relevance 0.42
It should be noted that the action of IL-6 is downstream of IL-1, as both induction of IL-6 and activation of HPA axis are inhibited by transgenic inactivation of type I IL-1 receptor (698).
Negative_regulation (inhibited) of Positive_regulation (activation) of HPA associated with targeted disruption
4) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.77 Pain Relevance 0.18
Deafferentation of the hypothalamus or surgical removal of the medial hypothalamus does not abolish the activation of the HPA axis by endotoxin (683, 684).
Neg (not) Negative_regulation (abolish) of Positive_regulation (activation) of HPA in hypothalamus associated with deafferentation
5) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.63 Pain Relevance 0.19
Indeed, in CRH knockout mice that are still capable of a partial HPA activation via AVP (567), an IL-6 immunoneutralising antibody abolishes this HPA activation (686, 699).
Negative_regulation (abolishes) of Positive_regulation (activation) of HPA associated with targeted disruption
6) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.32 Pain Relevance 0.33

General Comments

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