INT336053

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.44
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
OGE 2
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 72.00 Quite High
palliative 1 10.64 Low Low
ischemia 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 95 98.08 Very High Very High Very High
Parkinson's Disease 1 87.36 High High
Death 17 82.84 Quite High
Injury 3 77.84 Quite High
Disease 1 72.36 Quite High
INFLAMMATION 2 72.00 Quite High
Stress 10 64.96 Quite High
Hepatocellular Cancer 5 24.08 Low Low
Cancer 16 16.72 Low Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first examined whether NCTD affects the activation of pro-caspase-8 in HepG2 cells.
Spec (whether) Regulation (affects) of Spec (whether) Positive_regulation (activation) of pro-caspase-8
1) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.93 Pain Relevance 0
Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8.
Neg (little) Regulation (effect) of Positive_regulation (activation) of caspase-8 in OGE
2) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952314 Disease Relevance 0.51 Pain Relevance 0.04

General Comments

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