INT3361

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2011
Negated 7
Speculated 9
Reported most in Abstract
Documents 273
Total Number 283
Disease Relevance 208.53
Pain Relevance 44.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
white blood cell 8
retina 7
microglia 7
erythrocyte 6
brain 6
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 62 100.00 Very High Very High Very High
Central nervous system 695 99.98 Very High Very High Very High
headache 64 99.96 Very High Very High Very High
Potency 100 99.92 Very High Very High Very High
rheumatoid arthritis 499 99.90 Very High Very High Very High
backache 86 99.90 Very High Very High Very High
agonist 563 99.84 Very High Very High Very High
Serotonin 191 99.84 Very High Very High Very High
Paracetamol 38 99.80 Very High Very High Very High
depression 37 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2251 100.00 Very High Very High Very High
INFLAMMATION 1724 100.00 Very High Very High Very High
Cancer 1130 100.00 Very High Very High Very High
Thiamine Deficiency 372 99.98 Very High Very High Very High
Disease 1992 99.96 Very High Very High Very High
Fever 134 99.96 Very High Very High Very High
Headache 112 99.96 Very High Very High Very High
Weight Loss 33 99.96 Very High Very High Very High
Miosis 1 99.96 Very High Very High Very High
Hearing Impairment 1 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevation of ESR and CRP titer were seen in 37.7%, and 36.1% of patients, respectively.
Positive_regulation (Elevation) of ESR
1) Confidence 0.69 Published 2008 Journal Acta Neurol Taiwan Section Body Doc Link 18686646 Disease Relevance 0.08 Pain Relevance 0
The clinical picture is characterized by a comparatively sudden onset of abdominal pain, obstipation and feaver as well as a markedly increased ESR.
Positive_regulation (increased) of ESR associated with abdominal pain
2) Confidence 0.69 Published 1976 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 992315 Disease Relevance 0.54 Pain Relevance 0.14
Seventy-three percent had an increased ESR.
Positive_regulation (increased) of ESR
3) Confidence 0.60 Published 1995 Journal Infection Section Abstract Doc Link 7622271 Disease Relevance 2.00 Pain Relevance 0.08
The analysis of 138 case records of acute mastoiditis (AM) patients treated for the last 5 years has demonstrated that mastoiditis incidence grows, it shows the trend to arise shortly after development of acute otitis media, classic symptoms occur less frequently while such symptoms as pain in the ear, pulse reflex, hypoacusis, elevated ESR are apparent.
Positive_regulation (elevated) of ESR in ear associated with pain, otitis media, mastoiditis and hearing impairment
4) Confidence 0.60 Published 2002 Journal Vestn. Otorinolaringol. Section Abstract Doc Link 12400127 Disease Relevance 0.56 Pain Relevance 0.10
Hemato-chemical tests performed during hospitalization showed only relative leukopenia and a significant increase of ESR.
Positive_regulation (increase) of ESR associated with leukopenia
5) Confidence 0.60 Published 2000 Journal Minerva Med. Section Abstract Doc Link 11037632 Disease Relevance 1.04 Pain Relevance 0.08
In the evaluation of our patient, four items were of particular importance: awareness of his previously documented S. aureus bacteremia, a markedly elevated ESR, an abnormal chest radiograph, and the positive bone scan.
Positive_regulation (elevated) of ESR in chest associated with bacteremia
6) Confidence 0.60 Published 1996 Journal Dig. Dis. Sci. Section Abstract Doc Link 8689935 Disease Relevance 0.60 Pain Relevance 0.17
She presented with the abrupt onset of severe back pain, proximal myalgia, and left knee synovitis, associated with an anemia and marked elevation of ESR.
Positive_regulation (elevation) of ESR in knee associated with anaemia, synovitis, myalgia and backache
7) Confidence 0.60 Published 1994 Journal R I Med Section Abstract Doc Link 8118070 Disease Relevance 1.51 Pain Relevance 0.33
A 79-year old female patient with antecedents of headache and fever, was admitted because of fatigue, anorexia, anemia and elevated ESR.
Positive_regulation (elevated) of ESR associated with appetite loss, anaemia, fatigue, headache and fever
8) Confidence 0.60 Published 1981 Journal Med Clin (Barc) Section Abstract Doc Link 7242167 Disease Relevance 0.76 Pain Relevance 0.16
An elevated ESR was found in 80 per cent of patients.
Positive_regulation (elevated) of ESR
9) Confidence 0.60 Published 1978 Journal Br J Surg Section Abstract Doc Link 719333 Disease Relevance 0.52 Pain Relevance 0.09
An increased ESR is a feature of this disease.
Positive_regulation (increased) of ESR associated with disease
10) Confidence 0.60 Published 2006 Journal Klin Med (Mosk) Section Abstract Doc Link 17087187 Disease Relevance 1.07 Pain Relevance 0.13
Laboratory findings were of minor value in the diagnosis since elevated ESR, white blood cell count, and body temperature were inconstant findings.
Positive_regulation (elevated) of ESR in white blood cell
11) Confidence 0.59 Published 1992 Journal Acta Orthop Scand Section Abstract Doc Link 1609596 Disease Relevance 0.43 Pain Relevance 0.18
This may be explained by either an increase in ER?
Positive_regulation (increase) of ER
12) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.60 Pain Relevance 0.18
ERB-79 increased the more ER?
Positive_regulation (increased) of ER
13) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.35 Pain Relevance 0.30
To avoid the over-diagnosis of PMR in patients with a low ESR, we propose a set of criteria that can be easily applied in daily practice to patients with a clinical picture consistent with PMR but with a normal or slightly increased ESR.
Positive_regulation (increased) of ESR
14) Confidence 0.53 Published 2000 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 10948758 Disease Relevance 0.37 Pain Relevance 0.05
The ospemifene treatment increased the ER score, whereas tamoxifen decreased it.
Positive_regulation (increased) of ER
15) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.23 Pain Relevance 0
Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.
Positive_regulation (required) of Estrogen receptor-alpha associated with opioid receptor
16) Confidence 0.49 Published 2003 Journal J. Neurosci. Res. Section Title Doc Link 12605406 Disease Relevance 0.37 Pain Relevance 0.74
The results of the present experiments indicate that ERalpha is required for estrogen-induced MOR internalization and suggest that ERalpha can mediate rapid actions of estrogen.
Positive_regulation (required) of ERalpha associated with opioid receptor
17) Confidence 0.49 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.34 Pain Relevance 0.60
The primer sequences of ER?
Positive_regulation (sequences) of ER
18) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.20 Pain Relevance 0
In the present study, immunohistochemical localization of the truncated ER?
Positive_regulation (truncated) of ER
19) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.74 Pain Relevance 0
Our current study and the study by Engdahl and colleagues confirm the important role of ER?
Positive_regulation (role) of ER
20) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.36 Pain Relevance 0.36

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