INT33612

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.65
Pain Relevance 6.00

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signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
brain 3
CHO 3
visceral 2
sensory neurons 1
neuronal 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 22 100.00 Very High Very High Very High
Somatostatin 8 100.00 Very High Very High Very High
Cholecystokinin 1 99.84 Very High Very High Very High
opiate 7 99.80 Very High Very High Very High
medulla 86 99.68 Very High Very High Very High
substance P 8 99.12 Very High Very High Very High
alcohol 10 99.00 Very High Very High Very High
Substantia nigra 1 98.20 Very High Very High Very High
withdrawal 10 97.44 Very High Very High Very High
agonist 38 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bacteremia 7 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 98.88 Very High Very High Very High
Salmonella Infection 6 98.32 Very High Very High Very High
Alcohol Addiction 5 97.76 Very High Very High Very High
Opportunistic Infections 4 95.76 Very High Very High Very High
Colon Cancer 1 90.20 High High
Adenocarcinoma 3 87.00 High High
Heart Rate Under Development 10 85.20 High High
Cough 7 85.04 High High
Disease 19 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of neurotensin (NT) to specific receptors triggers the multiple functions that NT exerts in both periphery and brain.
neurotensin Binding (binding) of in brain
1) Confidence 0.46 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.08 Pain Relevance 0.12
The binding of neurotensin (NT) to specific receptors triggers the multiple functions that NT exerts in both periphery and brain.
NT Binding (binding) of in brain
2) Confidence 0.46 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.08 Pain Relevance 0.12
Autoradiographic studies reveal densities of binding to somatostatin, neurotensin, mu-opiate, and benzodiazepine receptors in substantia nigra specimens from neurologically normal human brains.
neurotensin Binding (binding) of in brains associated with substantia nigra, somatostatin and opiate
3) Confidence 0.41 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 3019228 Disease Relevance 0.15 Pain Relevance 0.59
In addition, the transcriptional activation of the NTR gene was dependent on NT-receptor complex internalization and de novo protein synthesis.
NT Binding (internalization) of
4) Confidence 0.36 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.09 Pain Relevance 0.16
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
NT Binding (bind) of in CHO associated with antagonist
5) Confidence 0.33 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.30
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
neurotensin Binding (bind) of in CHO associated with antagonist
6) Confidence 0.33 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.31
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
NT Binding (bind) of in CHO associated with antagonist
7) Confidence 0.28 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.31
Jean et al. [53, 54] has shown the importance of the NTS as the “dorsal swallowing group” (DSG) in the brainstem swallowing control centers or “central pattern generator.”
NTS Binding (importance) of in brainstem associated with medulla
8) Confidence 0.24 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.15 Pain Relevance 0.21
Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon.
neurotensin Binding (Characterization) of in colon
9) Confidence 0.21 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11356931 Disease Relevance 0.09 Pain Relevance 0
Non-typhi Salmonellae (NTS) bacteremia was recognized early in the course of the human immunodeficiency virus (HIV) epidemic in Africa as a common and serious opportunistic infection [1].
NTS Binding (recognized) of associated with opportunistic infections, bacteremia and acquired immune deficiency syndrome or hiv infection
10) Confidence 0.20 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2933632 Disease Relevance 0.84 Pain Relevance 0
A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin, have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.
neurotensin Binding (interact) of associated with withdrawal, cholecystokinin and alcohol
11) Confidence 0.19 Published 1986 Journal Recent Dev Alcohol Section Abstract Doc Link 3010391 Disease Relevance 0.40 Pain Relevance 1.04
In close proximity to the NTS is the CMM which, like the NTS, receives visceral afferents including information from cardiovascular and arterial baroreceptors (e.g.
NTS Binding (proximity) of in visceral associated with medulla
12) Confidence 0.15 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.52 Pain Relevance 0.57
In close proximity to the NTS is the CMM which, like the NTS, receives visceral afferents including information from cardiovascular and arterial baroreceptors (e.g.
NTS Binding (receives) of in visceral associated with medulla
13) Confidence 0.15 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.59 Pain Relevance 0.60
Group A7 is also composed of receptors for peptide ligands: neuromedin, neurotensin, motilin, endothelin, bombesin and the releasing hormones for growth hormone and thyrotropin.
neurotensin Binding (ligands) of
14) Confidence 0.13 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.27
Mature NTs also bind to a structurally distinct receptor, p75, which affects neuronal development through downstream signaling.
NTs Binding (bind) of in neuronal
15) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.11 Pain Relevance 0.75
TRPV1 is widely expressed on sensory neurons innervating pharynx and larynx, projecting to NTS and colocalizes with SP [71].
NTS Binding (projecting) of in sensory neurons associated with substance p
16) Confidence 0.07 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929516 Disease Relevance 0.56 Pain Relevance 0.65

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