INT336169

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HIVEP1, CXCR4) cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4)
nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
Anatomy Link Frequency
T lymphocyte 1
HIVEP1 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 18.88 Low Low
headache 7 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 57 100.00 Very High Very High Very High
Sprains And Strains 16 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Headache 7 5.00 Very Low Very Low Very Low
Fatigue 4 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Fever 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first step of viral entry is for HIV to locate a T lymphocyte via the CD4 receptor site.14 After the T lymphocyte is bound, the virus must also bind to either a CCR5 (site of action of maraviroc) or CXCR4 coreceptor. 15 The viral membrane then proceeds to fuse with the host cell membrane, via GP 41 (site of action of efuvirtide), enabling its RNA and proteins to enter the T lymphocyte.
HIV Binding (bind) of CXCR4 in T lymphocyte associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.44 Pain Relevance 0

General Comments

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