INT336179

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.60
Pain Relevance 0

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generation of precursor metabolites and energy (DLST) mitochondrion (DLST) small molecule metabolic process (DLST)
plasma membrane (DLST) nucleus (DLST) transferase activity, transferring acyl groups (DLST)
CACNA1F (Homo sapiens)
DLST (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomatitis 5 99.40 Very High Very High Very High
Mucositis 6 98.96 Very High Very High Very High
Neutropenia 13 98.48 Very High Very High Very High
Thrombocytopenia 12 96.68 Very High Very High Very High
Toxicity 45 94.68 High High
Anastomotic Leak 1 83.68 Quite High
Ileus 1 79.92 Quite High
Wound Infection 1 78.76 Quite High
Ovarian Cancer 47 75.80 Quite High
Solid Tumor 5 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the evidences of a different toxicity profile, PLD safety has been also investigated in combinations involving two or even three agents:21–64 in the dose-finding studies exploring combinations of PLD with cisplatin (CDDP) (Table 2), the DLTs were mostly represented by mucositis, and also neutropenia when CDDP was used at doses > 60 mg/m2 every 28 days.21,22 Similarly, when combining PLD with carboplatin (JM8), DLTs consisting in stomatitis/mucositis were documented at PLD doses > 50 mg/m2, while thrombocytopenia was the most frequently reported DLT for lower PLD doses, with the exception of the study by Hamilton et al.25
JM8 Binding (combining) of DLTs associated with neutropenia, toxicity, stomatitis, mucositis and thrombocytopenia
1) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 1.60 Pain Relevance 0

General Comments

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