INT336195

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
3G3 2
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 68.24 Quite High
Ovarian Cancer 47 61.64 Quite High
Syndrome 28 13.40 Low Low
Toxicity 45 9.08 Low Low
Disease 22 6.80 Low Low
Neutropenia 13 5.00 Very Low Very Low Very Low
Thrombocytopenia 12 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 11 5.00 Very Low Very Low Very Low
Anaemia 8 5.00 Very Low Very Low Very Low
Mucositis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A summary of the ongoing trials investigating the combination of PLD with other growth factor receptor inhibitors such as IMC-3G3, an inhibitor of PDGF-R (NCT00913835), panitumumab (an EGF-R blocker) (NCT00861120), and pazopanib (which interferes with VEGF-R1,2,3 kinase, PDGF-R and c-kit oncogene product) (NCT01035658) can be found at the www.clinicaltrials.gov.
Negative_regulation (inhibitors) of Negative_regulation (inhibitor) of PDGF-R in 3G3
1) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.19 Pain Relevance 0

General Comments

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