INT3362

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 27
Disease Relevance 10.03
Pain Relevance 15.93

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methyltransferase activity (Emg1)
Anatomy Link Frequency
muscles 5
bladder 2
anterior 1
abdominal oblique muscle 1
genioglossus 1
Emg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 27 100.00 Very High Very High Very High
Acupuncture 108 99.68 Very High Very High Very High
Morphine 30 99.64 Very High Very High Very High
Action potential 10 99.28 Very High Very High Very High
Pain 105 99.24 Very High Very High Very High
Serotonin 9 98.96 Very High Very High Very High
halothane 3 98.64 Very High Very High Very High
narcan 12 98.62 Very High Very High Very High
adenocard 18 98.56 Very High Very High Very High
Abeta 10 98.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress Incontinence 74 100.00 Very High Very High Very High
Depression 25 100.00 Very High Very High Very High
Myalgia 14 99.24 Very High Very High Very High
Pain 77 98.32 Very High Very High Very High
Emergencies 21 97.86 Very High Very High Very High
Bites And Stings 98 95.92 Very High Very High Very High
Bruxism 98 94.44 High High
Temporomandibular Joint Syndrome 35 94.00 High High
Overactive Bladder 39 91.92 High High
Temporomandibular Joint Disorders 105 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In serotonin-depleted rats, however, high-frequency stimulation suppressed dEMG activity only slightly and induced a smaller proportion of type II neurons.
Negative_regulation (suppressed) of dEMG in type II neurons associated with serotonin
1) Confidence 0.57 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2975524 Disease Relevance 0 Pain Relevance 0.30
If this prerequisite is fulfilled, the NTI-tss splint may be particularly justified in the following clinical situations:

• A patient with acute and intense temporomandibular pain (possibly accompanied by a restricted jaw opening), who requires (as an emergency therapy) the rapid incorporation of an oral appliance to increase the vertical dimension of the jaws. • A reduction of the EMG activity of jaw closing muscles during jaw clenching or tooth grinding is desired.


Negative_regulation (reduction) of EMG in muscles associated with pain and emergencies
2) Confidence 0.50 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.67 Pain Relevance 0.30
In both investigations, the NTI-tss device, but not the occlusal stabilization appliance, showed a significant reduction of the EMG activity.
Negative_regulation (reduction) of EMG
3) Confidence 0.50 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.47 Pain Relevance 0.29
Data from other investigations suggests that a decrease of EMG activity may indeed be associated with a pain reduction in patients with masticatory muscle pain [38].
Negative_regulation (decrease) of EMG in muscle associated with pain and myalgia
4) Confidence 0.50 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.70 Pain Relevance 0.42
These findings are compatible with early results from Van Eijden et al [37] who found that maximal effort clenches on the incisal edges of the incisors resulted in a significant decline of EMG activity as compared to clenching in intercuspation.
Negative_regulation (decline) of EMG in incisors
5) Confidence 0.50 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.87 Pain Relevance 0.65
Moreover, a decrease of EMG activity is not a unique characteristic of the NTI-tss device, but may be achieved with any anterior bite stop [39], sometimes even with a full-coverage occlusal appliance [38].
Negative_regulation (decrease) of EMG in anterior associated with bites and stings
6) Confidence 0.50 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.70 Pain Relevance 0.40
The periurethral electromyogram (EMG) activity was excited when the bladder was contracted, and EMG activity was inhibited when the bladder was relaxed by NC-1800.
Negative_regulation (inhibited) of EMG in bladder
7) Confidence 0.38 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9298929 Disease Relevance 0.34 Pain Relevance 0.04
Acupuncture-like stimulation of the bulbocavernosus, which partly overlies the proximal urethra produced depression of EMG activity in 50% of trials, but the incidence of similar effects from the more distant pubococcygeus, or the dorsal or ventral sacrococcygeal muscles was about 90-100%.
Negative_regulation (depression) of EMG in muscles associated with stress incontinence, depression and acupuncture
8) Confidence 0.38 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532213 Disease Relevance 0.78 Pain Relevance 0.59
Depression of EMG activity with a duration of more than 3 min was consistently seen from the muscles at the base of the tail (sacrococcygeus) and perineal area (pubococcygeus and bulbocavernosus).
Negative_regulation (Depression) of EMG in muscles associated with depression
9) Confidence 0.38 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532213 Disease Relevance 0.82 Pain Relevance 0.51
Depression of EMG activity was seen predominantly during stimulation of structures close to the urethra, but not opposed to it.
Negative_regulation (Depression) of EMG in urethra associated with stress incontinence and depression
10) Confidence 0.38 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532213 Disease Relevance 0.74 Pain Relevance 0.55
When acupuncture-like stimuli were applied only to structure beneath the skin, depression of EMG activity usually occurred.
Negative_regulation (depression) of EMG in skin associated with depression and acupuncture
11) Confidence 0.38 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532213 Disease Relevance 0.78 Pain Relevance 0.59
In the present study, an electromyogram (EMG) of the external abdominal oblique muscle evoked by colorectal distention was measured as a visceromotor reflex response, and inhibitory effects of LC/SC stimulation were estimated by the decrease of EMG activity.
Negative_regulation (decrease) of EMG in abdominal oblique muscle
12) Confidence 0.38 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882797 Disease Relevance 0 Pain Relevance 0.23
The Hoku stimulation also produced the suppression of the EMG activity without the increase of the threshold temperature.
Negative_regulation (suppression) of EMG
13) Confidence 0.38 Published 1987 Journal Am. J. Chin. Med. Section Abstract Doc Link 3425572 Disease Relevance 0 Pain Relevance 0.49
The Zusanli stimulation decreased the EMG activity, but the threshold temperature did not change.
Negative_regulation (decreased) of EMG
14) Confidence 0.38 Published 1987 Journal Am. J. Chin. Med. Section Abstract Doc Link 3425572 Disease Relevance 0 Pain Relevance 0.46
[21] have shown that – when compared to baseline EMG recordings from the masseter muscle during sleep – insertion of the NTI-tss device leads to a significant reduction in EMG activity of jaw closing muscles during clenching or grinding.
Negative_regulation (reduction) of EMG in muscle
15) Confidence 0.37 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2583977 Disease Relevance 0.86 Pain Relevance 0.68
2006, Jadad score: 2); in both studies, compared to an occlusal stabilization splint the NTI-tss device showed significant reduction of EMG activity.
Negative_regulation (reduction) of EMG
16) Confidence 0.37 Published 2008 Journal BMC Oral Health Section Abstract Doc Link PMC2583977 Disease Relevance 0.99 Pain Relevance 0.62
The results showed that: 1) NE (3, 6, or 12 nmol) or 5-HT (60, 120, or 240 nmol) each produced a dose-dependent suppression of FR EMG, respectively; 2) pretreatment with Gli (5, 10, or 20 nmol) antagonized the NE (6 nmol)-induced antinociception in a dose-dependent manner and failed to modulate the 5-HT (120 nmol)-induced suppression of FR EMG; 3) pretreatment with Gli (5, 10, or 20 nmol) also antagonize the Mor (2 nmol)-induced suppression of FR EMG in a dose-dependent manner; 4) pretreatment with naloxone (Nal, 60, 120, or 240 nmol) also antagonize the NE (6 nmol)-induced suppression of FR EMG in a dose-dependent manner; and 5) NECA (0.5, 1.0, or 2.0 nmol) produced a dose-dependent suppression of FR EMG, while pretreatment with Gli (5, 10, or 20 nmol) failed to modulate the NECA (1.0 nmol)-induced suppression of FR EMG.
Negative_regulation (suppression) of FR EMG associated with antinociception, adenocard, narcan and morphine
17) Confidence 0.31 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9510418 Disease Relevance 0 Pain Relevance 1.28
The results showed that: 1) NE (3, 6, or 12 nmol) or 5-HT (60, 120, or 240 nmol) each produced a dose-dependent suppression of FR EMG, respectively; 2) pretreatment with Gli (5, 10, or 20 nmol) antagonized the NE (6 nmol)-induced antinociception in a dose-dependent manner and failed to modulate the 5-HT (120 nmol)-induced suppression of FR EMG; 3) pretreatment with Gli (5, 10, or 20 nmol) also antagonize the Mor (2 nmol)-induced suppression of FR EMG in a dose-dependent manner; 4) pretreatment with naloxone (Nal, 60, 120, or 240 nmol) also antagonize the NE (6 nmol)-induced suppression of FR EMG in a dose-dependent manner; and 5) NECA (0.5, 1.0, or 2.0 nmol) produced a dose-dependent suppression of FR EMG, while pretreatment with Gli (5, 10, or 20 nmol) failed to modulate the NECA (1.0 nmol)-induced suppression of FR EMG.
Negative_regulation (suppression) of FR EMG associated with antinociception, adenocard, narcan and morphine
18) Confidence 0.31 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9510418 Disease Relevance 0 Pain Relevance 1.20
The results showed that: 1) NE (3, 6, or 12 nmol) or 5-HT (60, 120, or 240 nmol) each produced a dose-dependent suppression of FR EMG, respectively; 2) pretreatment with Gli (5, 10, or 20 nmol) antagonized the NE (6 nmol)-induced antinociception in a dose-dependent manner and failed to modulate the 5-HT (120 nmol)-induced suppression of FR EMG; 3) pretreatment with Gli (5, 10, or 20 nmol) also antagonize the Mor (2 nmol)-induced suppression of FR EMG in a dose-dependent manner; 4) pretreatment with naloxone (Nal, 60, 120, or 240 nmol) also antagonize the NE (6 nmol)-induced suppression of FR EMG in a dose-dependent manner; and 5) NECA (0.5, 1.0, or 2.0 nmol) produced a dose-dependent suppression of FR EMG, while pretreatment with Gli (5, 10, or 20 nmol) failed to modulate the NECA (1.0 nmol)-induced suppression of FR EMG.
Negative_regulation (suppression) of FR EMG associated with antinociception, adenocard, narcan and morphine
19) Confidence 0.31 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9510418 Disease Relevance 0 Pain Relevance 0.98
In the premedicated case, no suppression of the dEMG occurred.
Neg (no) Negative_regulation (suppression) of dEMG
20) Confidence 0.25 Published 1978 Journal Jpn. J. Physiol. Section Abstract Doc Link 722993 Disease Relevance 0 Pain Relevance 0.90

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