INT33630

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Context Info
Confidence 0.09
First Reported 1983
Last Reported 2001
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.95
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r) plasma membrane (Ltb4r) signal transducer activity (Ltb4r)
Anatomy Link Frequency
leukocyte 1
nerve 1
PGE2 1
PMN 1
Ltb4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 2 99.92 Very High Very High Very High
Hyperalgesia 6 99.68 Very High Very High Very High
Inflammation 23 99.36 Very High Very High Very High
Pain 7 99.08 Very High Very High Very High
cINOD 6 98.86 Very High Very High Very High
Potency 1 94.12 High High
antagonist 2 88.40 High High
epidural 4 85.12 High High
cytokine 5 84.32 Quite High
Pain threshold 1 62.48 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.68 Very High Very High Very High
Pressure And Volume Under Development 3 99.48 Very High Very High Very High
INFLAMMATION 21 99.36 Very High Very High Very High
Pain 6 99.08 Very High Very High Very High
Intervertebral Disk Displacement 1 81.32 Quite High
Necrosis 1 77.56 Quite High
Cancer 1 77.20 Quite High
Pleurisy 3 76.52 Quite High
Crystal Associated Disease 2 75.28 Quite High
Nerve Root Compression 1 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to examine the roles of TXA2 and LTB4 in the hyperalgesia induced by application of nucleus pulposus to the lumbar nerve root in the rat.
Spec (examine) Regulation (roles) of LTB4 in nerve associated with hyperalgesia
1) Confidence 0.09 Published 2001 Journal J. Orthop. Res. Section Abstract Doc Link 11398862 Disease Relevance 0.58 Pain Relevance 0.73
Time course studies demonstrated that the inhibitor effects of BW755C and phenidone on leukocyte recruitment reflected a reduction in the PGE2 but not the LTB4 content of the inflammatory exudate.
Neg (not) Regulation (reflected) of LTB4 in leukocyte associated with inflammation
2) Confidence 0.06 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.50 Pain Relevance 0.39
Both NSAIDs also reduced the content of PGE2 in the exudate without affecting LTB4 levels.
Neg (without) Regulation (affecting) of LTB4 in PGE2 associated with cinod
3) Confidence 0.06 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.67 Pain Relevance 0.39
As with BW755C, there was a differential effect on PMN and LTB4: dexamethasone (1 mg kg-1) reduced PMN accumulation by 40% but LTB4 formation was inhibited by 70%.
Regulation (effect) of LTB4 in PMN associated with dexamethasone
4) Confidence 0.05 Published 1983 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6141244 Disease Relevance 0.40 Pain Relevance 0.50
In the present studies in rats, the effects of LTB4 and LTD4 on edema and pain thresholds were examined in combination with PGE1 and/or brewer's yeast.
Regulation (effects) of LTB4 associated with pain and pressure and volume under development
5) Confidence 0.00 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6304817 Disease Relevance 0.80 Pain Relevance 0.47

General Comments

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