INT3364

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Context Info
Confidence 0.47
First Reported 1978
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 87
Total Number 90
Disease Relevance 31.93
Pain Relevance 17.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
condyle 6
heart 3
bone marrow 2
brain 2
blood 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 15 100.00 Very High Very High Very High
opiate 13 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Botox 5 100.00 Very High Very High Very High
Chronic pancreatitis 4 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
Hsan 2 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
reflex sympathetic dystrophy 2 99.98 Very High Very High Very High
Pain 103 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 64 100.00 Very High Very High Very High
Pancreatitis 4 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 4 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia 3 100.00 Very High Very High Very High
Neurofibromatosis 3 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 2 100.00 Very High Very High Very High
Spasticity 1 100.00 Very High Very High Very High
Stress 16 99.98 Very High Very High Very High
Lung Cancer 25 99.90 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 9 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: 1) To confirm linkage of hereditary sensory neuropathy type 1 (HSN-I) to human chromosome 9q22 in a large American family of German origin. 2) To construct a yeast artificial chromosome (YAC) contig spanning the HSN-I candidate interval. 3) To investigate the HSN-I contig for potential candidate genes.
type Binding (linkage) of associated with hsan
1) Confidence 0.47 Published 1999 Journal Neurology Section Abstract Doc Link 10025779 Disease Relevance 0.17 Pain Relevance 0.17
Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans.
type Binding (binds) of in myocardium associated with myocardial infarction
2) Confidence 0.47 Published 2002 Journal Cardiovasc. Res. Section Title Doc Link 11744022 Disease Relevance 0.37 Pain Relevance 0.21
Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with gamma-aminobutyric acid (GABA) type A receptors (GABAARs) and strychnine-sensitive glycine receptors in the rat central nervous system.
type Binding (interact) of in central nervous system associated with gaba, inflammation, analgesic and central nervous system
3) Confidence 0.47 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806306 Disease Relevance 0.10 Pain Relevance 0.32
The GH response to D was blunted by prior administration of naloxone, suggesting that D interacts with mu-type opiate receptors.
type Binding (interacts) of associated with narcan and opiate
4) Confidence 0.47 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6633818 Disease Relevance 0 Pain Relevance 0.30
The acute sarcoid reaction is associated with a distinct HLA type and resolves spontaneously in 1 to 6 months.
type Binding (associated) of associated with sarcoidosis
5) Confidence 0.47 Published 1993 Journal Curr Opin Rheumatol Section Abstract Doc Link 8435295 Disease Relevance 1.70 Pain Relevance 0.26
Type II EBSs bound tamoxifen and quercetin with similar affinity.
Type Binding (bound) of
6) Confidence 0.47 Published 1997 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9224209 Disease Relevance 0.59 Pain Relevance 0
Candesartan differs from other agents in its class in that it is tightly bound to angiotensin II type 1 receptors, allowing prolonged activity.
type Binding (bound) of
7) Confidence 0.47 Published 2000 Journal Am J Health Syst Pharm Section Abstract Doc Link 10786259 Disease Relevance 0 Pain Relevance 0
The comparison of low-energy backbone structures of DM, DM 1-5 and its analogues resulted in development of the dermorphin "biologically active" conformation being characteristic of its binding with mu-type receptors.
type Binding (binding) of
8) Confidence 0.47 Published 1989 Journal Bioorg. Khim. Section Abstract Doc Link 2556149 Disease Relevance 0 Pain Relevance 0.09
Three chemical families, dihydropyridines (DHP), phenylalkylamines (verapamil) and benzothiazepines (diltiazem) bind to the type L receptors of the calcium channels with different binding, modulation and tissue selectivity characteristics.
type Binding (bind) of associated with calcium channel
9) Confidence 0.47 Published 1997 Journal J Mal Vasc Section Abstract Doc Link 9411006 Disease Relevance 0.23 Pain Relevance 0.22
The neurosteroid allopregnanolone (ALLO) or 3alpha-OH-5alpha-pregnane-20-one interacts with the GABA type A receptor chloride ion channel complex and enhances the effect of GABA.
type Binding (interacts) of associated with gaba
10) Confidence 0.47 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938407 Disease Relevance 0.25 Pain Relevance 0.29
We report the association of a cutaneous lesion with multiple endocrine neoplasia type 2A (MEN 2A) in three patients from a French family.
type Binding (association) of associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
11) Confidence 0.47 Published 1992 Journal Presse Med Section Abstract Doc Link 1348355 Disease Relevance 0.86 Pain Relevance 0.25
The majority of cases are sporadic although the association of this lesion with familial neurofibromatosis (NF) type 2 is well known.
type Binding (association) of associated with neurofibromatosis
12) Confidence 0.47 Published 2006 Journal Neurocirugia (Astur) Section Abstract Doc Link 16855783 Disease Relevance 0.42 Pain Relevance 0.04
The different effects of dexamethasone and hydrocortisone raise the possibility that sympatho-adrenomedullary activation after morphine is influenced by the interaction of cortisol with type I glucocorticoid receptors which have a low affinity for dexamethasone and a high affinity for cortisol.
type Binding (interaction) of associated with dexamethasone and morphine
13) Confidence 0.47 Published 1991 Journal Pain Section Abstract Doc Link 1749637 Disease Relevance 0.48 Pain Relevance 1.10
A series of interpenetrating polymer network (IPN) hydrogels was fabricated by simultaneously photocuring MG crosslinked by poly(ethylene glycol) diacrylate and chemically crosslinking type I collagen with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide.
type Binding (crosslinking) of in poly associated with ipn
14) Confidence 0.47 Published 2010 Journal Acta Biomater Section Abstract Doc Link 19632359 Disease Relevance 0 Pain Relevance 0.23
These clinical observations are consistent with a single site of interaction at the gamma-aminobutyric acid type A receptor.


type Binding (interaction) of
15) Confidence 0.47 Published 2006 Journal Anesthesiology Section Body Doc Link 16732087 Disease Relevance 0 Pain Relevance 0
Multiple epiphyseal dysplasia (MED) is a rare autosomal dominant skeletal dysplasia caused by abnormalities in the gene(s) coding for type IX collagen and cartilage oligomeric matrix protein.
type Binding (coding) of in cartilage associated with osteochondrodysplasias, congenital anomalies and cleidocranial dysplasia
16) Confidence 0.36 Published 2009 Journal J Arthroplasty Section Abstract Doc Link 18789631 Disease Relevance 0.84 Pain Relevance 0.20
B. henselae was isolated from the kitten and its DNA found to be for 16S rRNA type I by PCR.
type Binding (be) of
17) Confidence 0.36 Published 2000 Journal J. Vet. Med. Sci. Section Abstract Doc Link 11193351 Disease Relevance 0.86 Pain Relevance 0.24
[A case of multiple endocrine neoplasia type 2A (MEN2A) with a mutation in the RET gene].
type Binding (case) of associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
18) Confidence 0.36 Published 1999 Journal Hinyokika Kiyo Section Title Doc Link 10442282 Disease Relevance 0.78 Pain Relevance 0.14
It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells.
type Binding (associated) of in epithelial cells associated with apoptosis
19) Confidence 0.36 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.79 Pain Relevance 0
Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease.
type Binding (association) of in coronary artery associated with coronary artery disease and cva
20) Confidence 0.36 Published 2002 Journal Blood Section Title Doc Link 12149201 Disease Relevance 1.14 Pain Relevance 0.36

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