INT336457

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 48
Disease Relevance 3.78
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (MGAT1) Golgi apparatus (MGAT1) carbohydrate metabolic process (MGAT1)
Anatomy Link Frequency
joint 1
internal 1
MGAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 240 99.12 Very High Very High Very High
Osteoarthritis 96 64.40 Quite High
rheumatoid arthritis 48 45.12 Quite Low
Piles 48 5.00 Very Low Very Low Very Low
psoriasis 48 5.00 Very Low Very Low Very Low
fibrosis 48 5.00 Very Low Very Low Very Low
Pain 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 144 99.64 Very High Very High Very High
INFLAMMATION 192 99.12 Very High Very High Very High
Disease 336 98.86 Very High Very High Very High
Aspergillus Infection 48 96.88 Very High Very High Very High
Endometriosis (extended) 48 94.44 High High
Toxicity 192 91.92 High High
Shock 96 91.04 High High
Pressure And Volume Under Development 192 88.00 High High
Insulin Resistance 48 72.88 Quite High
Congenital Anomalies 48 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lee et al. (2007) also developed a method to produce Neu5Ac using recombinant whole cells that express GlcNAc 2-epimerase and recombinant Neu5Ac lyase separately [136].
Gene_expression (express) of GlcNAc
1) Confidence 0.09 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.12 Pain Relevance 0
This continuous production system is capable of producing GlcNAc at an average productivity of 78 g/L/h.
Gene_expression (producing) of GlcNAc
2) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
However, the enzymatic hydrolysis of chitin can produce GlcNAc under mild conditions.
Gene_expression (produce) of GlcNAc
3) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Production of GlcNAc by biotransformation
Gene_expression (Production) of GlcNAc
4) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
The two-stage bioreactors are operated continuously over a 10-day period, reaching steady-state production levels after 28 h, and this system is estimated to be an economic process for the production of GlcNAc.

2.4.

Gene_expression (production) of GlcNAc
5) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
This result indicates that it is possible to produce GlcNAc using whole microbes [87].
Gene_expression (produce) of GlcNAc
6) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Although economic processes to produce GlcNAc by enzymatic hydrolysis have been established, the necessity to arrange so many units is a limiting factor.
Gene_expression (produce) of GlcNAc
7) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
In this procedure, up to 6.42 g/L GlcNAc can be produced in 1 h [50].
Gene_expression (produced) of GlcNAc
8) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.06 Pain Relevance 0
The most common source of chitin for producing GlcNAc is shellfish biomass.
Gene_expression (source) of GlcNAc
9) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.06 Pain Relevance 0
In the fourth unit, a novel two-stage chitin-hydrolysis bioreactor was designed to maintain a high rate of chitin hydrolysis and GlcNAc production.
Gene_expression (production) of GlcNAc
10) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Thus, the chitin crystalline structure and the enzymatic composition of the reaction are two crucial factors in the production of GlcNAc through enzymatic methods.

2.3.

Gene_expression (production) of GlcNAc
11) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.07 Pain Relevance 0
Although the production of GlcNAc by chemical methods is estimated to be sufficiently economic, the product is not considered a natural material due to its chemical modification [51].
Gene_expression (production) of GlcNAc
12) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Enzymatic methods to produce GlcNAc
Gene_expression (produce) of GlcNAc
13) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Another way to produce GlcNAc is through the genetic modification of microorganisms using glucose as a substrate.
Gene_expression (produce) of GlcNAc
14) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.07 Pain Relevance 0
However, there appears to be several problems in producing GlcNAc by the direct acid hydrolysis of chitin, including high cost, low yield (below 65%) and acidic waste created by the use of HCl [51].
Gene_expression (producing) of GlcNAc
15) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.06 Pain Relevance 0
GlcNAc can be produced using fungal biomass as a substrate.
Gene_expression (produced) of GlcNAc
16) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
-chitin and to produce GlcNAc efficiently [51].
Gene_expression (produce) of GlcNAc
17) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.28 Pain Relevance 0
An additional N-acetylation reaction must then be performed to produce GlcNAc.
Gene_expression (produce) of GlcNAc
18) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
Another option to stabilize the chitin source for the production of GlcNAc is to utilize a non-shellfish chitin source.
Gene_expression (production) of GlcNAc
19) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0
A novel chitin-degrading microbe named Chitinibacter tainanensis was isolated from a soil sample that was collected in southern Taiwan and was proven to produce GlcNAc [88].
Gene_expression (produce) of GlcNAc
20) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0 Pain Relevance 0

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