INT336561

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DDC, DIO2) cellular nitrogen compound metabolic process (DDC, DIO2) cytosol (DDC)
lyase activity (DDC) plasma membrane (DIO2) cellular amino acid metabolic process (DDC)
Anatomy Link Frequency
spinal cord 1
DDC (Homo sapiens)
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 65 100.00 Very High Very High Very High
Spinal cord 44 98.38 Very High Very High Very High
Dorsal horn 5 63.76 Quite High
dopamine receptor 1 59.36 Quite High
Migraine 5 49.96 Quite Low
Pain 7 47.76 Quite Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
spinal dorsal horn 2 5.00 Very Low Very Low Very Low
Dorsal column 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinsonian Disorders 1 90.80 High High
Poisoning 10 88.60 High High
Parkinson's Disease 36 88.04 High High
Headache 5 49.96 Quite Low
Sleep Disorders 3 49.44 Quite Low
Pain 6 43.80 Quite Low
Restless Legs Syndrome 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The diencephalic A11 area could be the major source of L-DOPA in the NHP spinal cord, where it may play a role in the modulation of sensorimotor integration through D2 and D3 receptors either directly or indirectly via dopamine formation in spinal dopa-decarboxylase-positives cells.



dopa-decarboxylase Binding (formation) of D2 in spinal cord associated with dopamine and spinal cord
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954154 Disease Relevance 0.27 Pain Relevance 0.24

General Comments

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