INT336571

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD5) signal transducer activity (DRD5)
Anatomy Link Frequency
dorsal 1
spinal cord 1
ventral 1
DRD5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 15 99.68 Very High Very High Very High
Spinal cord 132 99.40 Very High Very High Very High
dopamine receptor 3 98.94 Very High Very High Very High
Dopamine 195 91.72 High High
Migraine 15 88.48 High High
Pain 21 86.28 High High
Locus ceruleus 9 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
spinal dorsal horn 6 5.00 Very Low Very Low Very Low
Dorsal column 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 15 88.48 High High
Sleep Disorders 9 87.96 High High
Pain 18 82.32 Quite High
Parkinson's Disease 108 54.88 Quite High
Poisoning 30 49.76 Quite Low
Parkinsonian Disorders 3 46.08 Quite Low
Restless Legs Syndrome 30 5.00 Very Low Very Low Very Low
Disease 21 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, D2, D3 and D5 receptor subtypes were expressed in the lumbar spinal cord sections.
Gene_expression (expressed) of D5 receptor in spinal cord associated with spinal cord
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.11 Pain Relevance 0.47
In situ hybridization of spinal dopamine receptors showed that D1 receptor mRNA is absent while D2 and D5 receptor mRNAs are mainly expressed in the dorsal horn and D3 receptor mRNA in both the dorsal and ventral horns.
Neg (absent) Gene_expression (expressed) of D5 receptor in ventral associated with dopamine receptor and dorsal horn
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954154 Disease Relevance 0.31 Pain Relevance 0.47
In situ hybridization of spinal dopamine receptors showed that D1 receptor mRNA is absent while D2 and D5 receptor mRNAs are mainly expressed in the dorsal horn and D3 receptor mRNA in both the dorsal and ventral horns.
Neg (absent) Gene_expression (expressed) of D5 receptor in dorsal associated with dopamine receptor and dorsal horn
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954154 Disease Relevance 0.31 Pain Relevance 0.47

General Comments

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