INT336580

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.67
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCRTR1) signal transducer activity (HCRTR1)
HCRTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 4 86.08 High High
depression 4 82.48 Quite High
Neuropeptide 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 348 98.72 Very High Very High Very High
Hypersomnia 152 98.68 Very High Very High Very High
Idiopathic Hypersomnolence 100 94.64 High High
Hallucination 20 93.36 High High
Sleep Paralysis 16 92.08 High High
Depression 4 82.48 Quite High
Autoimmune Disease 8 80.56 Quite High
Disease Progression 12 69.76 Quite High
Obesity 28 68.76 Quite High
Disease 36 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.016), or mean sleep latency with levels of immune complexes of hypocretin-1 IgA autoAbs (r?
hypocretin-1 IgA Binding (complexes) of
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.62 Pain Relevance 0
The composition of immune complexes of hypocretin-1 autoAbs is most likely with anti-idiotypic autoAbs since increased levels of such autoAbs was found in all three groups of patients with central hypersomnia.
hypocretin Binding (complexes) of associated with hypersomnia
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.74 Pain Relevance 0
Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for ?
hypocretin-1 IgG Binding (complexes) of associated with sleep disorders
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.68 Pain Relevance 0
Nevertheless, considering the eventual complementarities between the paratope of anti-idiotypic autoAbs and the antigen, which is in this case hypocretin-1 peptide or a cross-reacting protein, one cannot exclude binding of these autoAbs to the hypocretin receptors.
hypocretin Binding (binding) of
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.63 Pain Relevance 0.13

General Comments

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