INT3366

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 44
Total Number 44
Disease Relevance 15.83
Pain Relevance 9.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 28
plasma 9
endothelial cells 1
smooth muscle 1
monocytes 1
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 61 100.00 Very High Very High Very High
Serotonin 47 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Inflammation 85 99.86 Very High Very High Very High
Enkephalin 19 99.80 Very High Very High Very High
metalloproteinase 35 99.66 Very High Very High Very High
aspirin 224 99.64 Very High Very High Very High
Migraine 23 99.40 Very High Very High Very High
corticosteroid 11 98.82 Very High Very High Very High
Angina 42 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 81 100.00 Very High Very High Very High
Asthma 36 100.00 Very High Very High Very High
Thrombosis 123 99.90 Very High Very High Very High
INFLAMMATION 101 99.86 Very High Very High Very High
Headache 28 99.40 Very High Very High Very High
Coronary Heart Disease 37 99.36 Very High Very High Very High
Cardiovascular Disease 96 99.32 Very High Very High Very High
Vasculitis 7 99.16 Very High Very High Very High
Bacterial Respiratory Disease 4 99.12 Very High Very High Very High
Cluster Headache 1 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the rise in plasma levels of linoleic acid in migraine could be responsible for the platelet serotonin release observed during the attack.
Localization (release) of platelet in plasma associated with migraine and serotonin
1) Confidence 0.78 Published 1978 Journal Res Clin Stud Headache Section Abstract Doc Link 725245 Disease Relevance 0.34 Pain Relevance 0.52
The calcium blocking effect was studied in rabbit aorta while the modulatory role of ST on platelet serotonin release was evaluated in human platelets.
Localization (release) of platelet in platelet associated with serotonin
2) Confidence 0.78 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15507343 Disease Relevance 0.16 Pain Relevance 0.30
Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression.
Localization (release) of platelet in plasma
3) Confidence 0.78 Published 2009 Journal J. Orthop. Res. Section Title Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.03
Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression.
Localization (release) of platelet in plasma
4) Confidence 0.78 Published 2009 Journal J. Orthop. Res. Section Title Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.03
Finally, heparin is antagonized by platelet factor 4, which is released during aggregation, and by fibrin II monomers, which are a split product from fibrin formed to stabilize the thrombus [44,45].
Localization (released) of platelet in platelet associated with thrombosis
5) Confidence 0.78 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.17 Pain Relevance 0.38
Aggregation is also fostered by platelet activating factor (PAF), a cytokine secreted by neutrophil and monocytes as well as platelets [59].
Localization (secreted) of platelet in monocytes associated with cytokine
6) Confidence 0.78 Published 2002 Journal Nutr J Section Body Doc Link PMC139960 Disease Relevance 0.44 Pain Relevance 0.13
In vitro, thrombin released platelet-met-enkephalin IR concomitantly with 5-hydroxytryptamine (5-HT), suggesting a common subcellular localization, i.e. the 5-HT storing organelles, for met-enkephalin IR and the amine.
Localization (released) of platelet in platelet associated with enkephalin
7) Confidence 0.78 Published 1982 Journal Life Sci. Section Abstract Doc Link 7098767 Disease Relevance 0.07 Pain Relevance 0.85
Platelets release serotonin upon activation (Fig. 2c) and the neuronal membrane is facilitated by a calcium dependent excitation-excretion coupling mechanism.
Localization (release) of Platelet in Platelets associated with serotonin
8) Confidence 0.78 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 0.57 Pain Relevance 0.44
Platelet rich plasma (PRP) has recently been investigated for use in tissue regeneration studies that seek to utilize the numerous growth factors released from platelet alpha-granules.
Localization (released) of platelet in PRP
9) Confidence 0.78 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17106885 Disease Relevance 0 Pain Relevance 0
The plasma levels of a platelet-specific protein, low affinity platelet factor 4 (LA-PF4), rose from less than 0.5 to 16 +/- 3 SEM microgram/ml plasma, indicating extensive release of platelet alpha granule contents.
Localization (release) of platelet in plasma
10) Confidence 0.78 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0 Pain Relevance 0.13
Of note, there repeatedly have been observations about a use of low-dose aspirin in primary prevention of certain solid tumors, which on a speculative base could be in connection with a potential proangiogenic effect of platelet secreted mediators such as platelet-derived growth factor (Dube et al 2007).
Localization (secreted) of platelet in platelet associated with aspirin and solid tumor
11) Confidence 0.78 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.35 Pain Relevance 0.21
The relevance of the bovine platelet serotonin release inhibition bioassay to antimigraine research is discussed.
Localization (release) of platelet in platelet associated with cluster headache and serotonin
12) Confidence 0.78 Published 1992 Journal J. Nat. Prod. Section Abstract Doc Link 1431933 Disease Relevance 0.26 Pain Relevance 0.31
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Localization (secreted) of platelet in platelets associated with acute coronary syndrome
13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.67 Pain Relevance 0
This study demonstrates that during extracorporeal circulation, release of lysosomal enzymes occurs concomitantly with platelet granule secretion.
Localization (secretion) of platelet in platelet
14) Confidence 0.78 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0 Pain Relevance 0
Eosinophils release a number of cytotoxic proteins, such as major basic protein, platelet activating factor and leukotrienes, which are responsible for the characteristic damage of the airway epithelium in allergic asthma [33,34].
Localization (release) of platelet in Eosinophils associated with asthma
15) Confidence 0.78 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.96 Pain Relevance 0.33
Rapid absorption following its intake and the mentioned irreversible binding to platelet cyclooxygenase lead to an inhibition of platelet function as soon as about one hour after intake of aspirin, an effect which lasts for several days (Patrono et al 2004).
Localization (cyclooxygenase) of platelet in platelet associated with aspirin
16) Confidence 0.73 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0 Pain Relevance 0.28
Coronary stents were deployed in almost 70% and adjunctive platelet GP IIb/IIIa blockade was administered in 36% of patients undergoing ad hoc PCI [35].
Localization (blockade) of platelet in platelet
17) Confidence 0.73 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59588 Disease Relevance 0.70 Pain Relevance 0.05
ng/mL MCP-1 induced a much lower level of THP-1 migration than TRAP-stimulated platelet releasate.
Localization (releasate) of platelet in THP-1
18) Confidence 0.73 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.16
Preparation of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP)
Localization (Preparation) of Platelet in PRP
19) Confidence 0.73 Published 2008 Journal Malar J Section Body Doc Link PMC2599902 Disease Relevance 0.17 Pain Relevance 0
Preparation of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP)
Localization (Preparation) of Platelet in PRP
20) Confidence 0.73 Published 2008 Journal Malar J Section Body Doc Link PMC2599902 Disease Relevance 0.17 Pain Relevance 0

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