INT336604

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp2a2) endoplasmic reticulum (Atp2a2) protein complex (Atp2a2)
Atp2a2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 97.04 Very High Very High Very High
ketamine 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 46 88.24 High High
Death 14 72.52 Quite High
Apoptosis 4 67.04 Quite High
Bacillus Anthracis Infection 56 50.00 Quite Low
Infection 22 30.24 Quite Low
Pressure And Volume Under Development 26 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 10 5.00 Very Low Very Low Very Low
Coronary Heart Disease 6 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somewhat surprisingly, prolonged in vivo exposure (18 hrs) failed to significantly affect expression of SERCA and phospholamban, suggesting presence of compensatory mechanism or time-dependence in lethal toxin-induced response on Ca2+ regulatory proteins.
Neg (failed) Regulation (affect) of Gene_expression (expression) of SERCA associated with addiction
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.21 Pain Relevance 0.05
In vitro exposure of lethal toxin (5 nM. 2 hrs) significantly down-regulated and up-regulated the expression of SERCA2a and phospholamban, respectively, the effects of which were partially restored or ablated by apocynin pretreatment (Fig. 9).


Regulation (regulated) of Gene_expression (expression) of SERCA2a
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.60 Pain Relevance 0

General Comments

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