INT33661

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.36
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)
Anatomy Link Frequency
neurons 1
brain 1
nasal 1
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 29 100.00 Very High Very High Very High
depression 18 100.00 Very High Very High Very High
TRP channel 12 100.00 Very High Very High Very High
Antinociceptive 3 99.98 Very High Very High Very High
Analgesic 1 99.68 Very High Very High Very High
primary afferent fibers 1 99.48 Very High Very High Very High
Intracerebroventricular 1 99.00 Very High Very High Very High
dorsal root ganglion 25 98.68 Very High Very High Very High
qutenza 20 98.42 Very High Very High Very High
Pain 53 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 18 100.00 Very High Very High Very High
Viral Sexually Transmitted Diseases 16 100.00 Very High Very High Very High
Fever 5 99.84 Very High Very High Very High
Nociception 14 99.48 Very High Very High Very High
Ganglion Cysts 57 98.68 Very High Very High Very High
Pain 40 97.56 Very High Very High Very High
Fatigue 24 97.08 Very High Very High Very High
Chlamydia Infection 8 96.52 Very High Very High Very High
Infection 31 95.20 Very High Very High Very High
Disease 11 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antinociceptive effects in rodents of the dipeptide Lys-Trp (Nps) and related compounds.
Regulation (effects) of Nps associated with antinociceptive
1) Confidence 0.44 Published 1986 Journal Peptides Section Title Doc Link 3012488 Disease Relevance 0.08 Pain Relevance 0.66
In particular, the involvement of TRP channels in nociception has been extensively studied following the cloning of the capsaicin receptor, TRPV1.
Regulation (involvement) of TRP associated with nociception, qutenza and trp channel
2) Confidence 0.44 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 0.85 Pain Relevance 0.50
Nybo et al. [8] however, found that brain uptake of Trp and Tyr as well as brain DA release were not affected by hyperthermia, failing therefore to support the classic "5-HT-central fatigue hypothesis" [37]; and also the involvement of brain DA function in thermoregulation during exercise in the heat.
Neg (not) Regulation (affected) of Trp in brain associated with dopamine, fatigue and fever
3) Confidence 0.17 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.61 Pain Relevance 0.48
These observations reveal distinct underlying mechanisms of TRP channel transcriptional regulation by cisplatin and oxaliplatin in DRG neurons.


Regulation (regulation) of TRP in neurons associated with dorsal root ganglion and trp channel
4) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.76 Pain Relevance 0.53
We determined the effect of EPO treatment on short-term depression (STD) and LTD at Schaffer collateral CA1 pathway (Figure 3i–l).
Spec (determined) Regulation (effect) of STD associated with depression
5) Confidence 0.07 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.75 Pain Relevance 0.55
In many cases the ingenious defensive strategies of plants to ward off herbivorous predators are based upon the production of chemical agents such as capsaicin, isothiocyanates, and thiosulfinates that produce their behavioral effects by targeting excitatory TRP channels on primary afferent nerve fibers of the trigeminal pain pathway within the nasal and oral cavities [4,5].
Regulation (targeting) of TRP in nasal associated with pain, trp channel, qutenza and primary afferent fibers
6) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.19 Pain Relevance 0.42
Offering hope for control of this STD is the development of a new point-of-care diagnostic [11,14,15].
Regulation (control) of STD associated with viral sexually transmitted diseases
7) Confidence 0.01 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1403785 Disease Relevance 1.67 Pain Relevance 0.12
No reports are available of IgA-reactive proteins and the role, if any, of this class of antibody in the control of this STD.
Regulation (control) of STD associated with viral sexually transmitted diseases
8) Confidence 0.01 Published 2006 Journal BMC Microbiol Section Abstract Doc Link PMC1403785 Disease Relevance 0.46 Pain Relevance 0

General Comments

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