INT336621

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 7.92
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fbln1) extracellular region (Fbln1) proteinaceous extracellular matrix (Fbln1)
extracellular matrix organization (Fbln1)
Fbln1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 36 100.00 Very High Very High Very High
fibrosis 9 94.00 High High
Inflammation 27 87.64 High High
anesthesia 9 77.08 Quite High
ketamine 9 39.44 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
Thoracotomy 9 5.00 Very Low Very Low Very Low
Immobilon 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 315 99.84 Very High Very High Very High
Airway Remodeling 72 99.62 Very High Very High Very High
Asthma 855 99.20 Very High Very High Very High
Occupational Lung Diseases 126 99.04 Very High Very High Very High
Fibrosis 9 94.00 High High
Fibrosarcoma 9 93.28 High High
INFLAMMATION 27 87.64 High High
Wound Healing 45 75.04 Quite High
Lung Injury 9 29.04 Quite Low
Stroke 18 26.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We were afforded the opportunity to study FBLN-1 levels in BAL fluid and serum from asthmatic volunteers both before and after administration of corticosteroids, and showed that treatment had no effect on FBLN-1.
Neg (no) Regulation (effect) of FBLN-1 associated with asthma and corticosteroid
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.67 Pain Relevance 0.16
Fibulin-1 is involved in wound repair in asthma derived ASM cells
Regulation (involved) of Fibulin-1 associated with asthma and injury
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.24 Pain Relevance 0
If, as our results in the present study suggest, FBLN-1 is implicated in airway remodeling, then the lack of effect of corticosteroids on levels of FBLN-1 in-vivo highlights the need for treatments that target the structural changes which contribute to airway remodeling in asthma.
Regulation (effect) of FBLN-1 associated with asthma, corticosteroid and airway remodeling
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.68 Pain Relevance 0.13
The differential regulation of the specific isoforms of FBLN-1 indicates that they may have opposing or compensatory effects [33].
Regulation (regulation) of FBLN-1
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.03 Pain Relevance 0
A series of AOs targeting FBLN-1 (5?
Regulation (targeting) of FBLN-1
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0 Pain Relevance 0.08
When these animals were treated with AOs targeting FBLN-1, TGF?
Regulation (targeting) of FBLN-1
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.60 Pain Relevance 0.08
However, these authors studied FBLN-1D, whilst in our studies, we designed our AO to target FBLN-1C, which appears to have different properties to the other FBLN-1 isoforms [33].
Regulation (target) of FBLN-1C
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.81 Pain Relevance 0
In addition to measuring FBLN-1 deposited in the ECM we also measured it in cell culture supernatants (soluble FBLN-1).
Regulation (measuring) of FBLN-1
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.43 Pain Relevance 0
Transfection of the FBLN-1C specific AO decreased FBLN-1C mRNA expression in asthmatic and non-asthmatic ASM derived cells compared with the transfection control (Effectene®) (P<0.05, P<0.01 respectively, figure 6A) whilst there were no changes in the mRNA levels of FBLN-1D (figure 6B).
Neg (no) Regulation (changes) of FBLN-1D associated with asthma
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.45 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox