INT336628

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 15.67
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fbln1) extracellular region (Fbln1) proteinaceous extracellular matrix (Fbln1)
extracellular matrix organization (Fbln1)
Anatomy Link Frequency
smooth muscle cells 1
Fbln1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 72 92.56 High High
cytokine 18 53.00 Quite High
Inflammation 54 50.00 Quite Low
ketamine 18 14.96 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
anesthesia 18 5.00 Very Low Very Low Very Low
Thoracotomy 18 5.00 Very Low Very Low Very Low
Immobilon 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 1710 99.84 Very High Very High Very High
Occupational Lung Diseases 252 99.56 Very High Very High Very High
Cancer 18 99.20 Very High Very High Very High
Injury 630 98.56 Very High Very High Very High
Wound Healing 90 95.00 High High
Disease 36 89.64 High High
Airway Remodeling 144 75.00 Quite High
Breast Cancer 36 65.60 Quite High
Fibrosarcoma 18 58.64 Quite High
Lung Injury 18 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the increased FBLN-1C levels in asthmatics contribute to wound repair and remodeling by increasing cell proliferation rather than cellular migration.
Positive_regulation (increased) of FBLN-1C associated with injury and occupational lung diseases
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.11 Pain Relevance 0
It was not possible to determine if this was due to an increase in FBLN-1C protein as a commercial antibody, which could distinguish between the FBLN-1 isoforms, was not available at the time of this study.
Positive_regulation (increase) of FBLN-1C protein
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.19 Pain Relevance 0.03
Although a global increase of FBLN-1 is associated with tumor cells [19], the FBLN-1 isoforms may have distinct, important roles in regulating cellular behavior.
Positive_regulation (increase) of FBLN-1 associated with cancer
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.66 Pain Relevance 0.03
We did not examine the FN levels in non-asthmatic ASM cells as we had not seen an induction of FBLN-1 in these cells.
Positive_regulation (induction) of FBLN-1 associated with asthma
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.17 Pain Relevance 0
Given our findings of increased FBLN-1 protein in asthmatic ASM cells and the lack of information about FBLN-1C we chose to elucidate the role of FBLN-1C in this study.
Positive_regulation (increased) of FBLN-1 protein associated with asthma
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.02 Pain Relevance 0
We did not examine the effect of knocking out FBLN-1C in the non-asthmatic ECM as we were unable to induce FBLN-1 in this matrix with TGF?.
Neg (unable) Positive_regulation (induce) of FBLN-1 associated with asthma
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.11 Pain Relevance 0
The increased FBLN-1 in the presence of TGF?
Positive_regulation (increased) of FBLN-1
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.21 Pain Relevance 0
not only increased FBLN-1 in asthma derived ASM cells, but also enhanced its deposition in the asthmatic ECM.
Positive_regulation (increased) of FBLN-1 associated with asthma
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.16 Pain Relevance 0
For measurement of FBLN-1 or its isotype control, a biotinylated sheep anti-mouse antibody (5 µg/mL) (Millipore) was then added followed by steptavidin HRP (0.5 µg/mL).
Positive_regulation (measurement) of FBLN-1
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.07 Pain Relevance 0
Predeveloped assay on demand primers were used as follows FBLN-1: Hs00242545_m1; FBLN-1C: Hs00242546_m1; FBLN-1D Hs00197774_m1 (Applied Biosystems, Foster City, CA, USA).
Positive_regulation (follows) of FBLN-1
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0 Pain Relevance 0
The increased FBLN-1 resulted in exaggerated proliferation and wound repair in asthma derived ASM cells which was reduced when only the FBLN-1C isoform was downregulated.
Positive_regulation (increased) of FBLN-1 associated with asthma and injury
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.70 Pain Relevance 0
upregulates fibulin-1C mRNA and FBLN-1 protein levels in ASM cells derived from people with asthma
Positive_regulation (upregulates) of FBLN-1 protein associated with asthma
12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.19 Pain Relevance 0.05
In addition fibulin-1 was increased in asthma derived airway smooth muscle cells and fibulin-1C contributed to the enhanced proliferation and wound repair in these cells.
Positive_regulation (increased) of fibulin-1 in smooth muscle cells associated with asthma and injury
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954173 Disease Relevance 0.65 Pain Relevance 0
upregulates fibulin-1C mRNA and FBLN-1 protein levels in ASM cells derived from people with asthma
Positive_regulation (upregulates) of fibulin-1C associated with asthma
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.18 Pain Relevance 0.05
Fibulin-1 levels are increased in serum and BAL fluid from asthmatic volunteers
Positive_regulation (increased) of Fibulin-1 associated with asthma
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.67 Pain Relevance 0.04
In-vivo, FBLN-1 levels were increased in BAL fluid and serum from asthmatic volunteers.
Positive_regulation (increased) of FBLN-1 associated with asthma
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.72 Pain Relevance 0
Levels of fibulin-1 were significantly increased in the serum and bronchoalveolar lavage fluid of 21 asthmatics compared with 11 healthy volunteers.
Positive_regulation (increased) of fibulin-1 associated with occupational lung diseases
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954173 Disease Relevance 0.65 Pain Relevance 0
induced FBLN-1C mRNA in the ASM cells derived from asthmatic volunteers (P<0.001) but did not increase the level of FBLN-1D mRNA, rather it decreased it (p<0.001, figure 2 C & D).
Neg (not) Positive_regulation (induced) of FBLN-1C mRNA associated with asthma
18) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.20 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox