INT33664

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.34
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LTA4H) peptidase activity (LTA4H) small molecule metabolic process (LTA4H)
nucleolus (LTA4H) nucleus (LTA4H) cytoplasm (LTA4H)
Anatomy Link Frequency
respiratory 1
LTA4H (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 23 99.84 Very High Very High Very High
Arthritis 2 94.88 High High
Inflammation 66 93.76 High High
Inflammatory response 2 79.52 Quite High
aspirin 11 61.12 Quite High
licofelone 8 56.64 Quite High
COX-2 inhibitor 10 14.28 Low Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 99.64 Very High Very High Very High
Respiratory Disease 2 97.36 Very High Very High Very High
Asthma 4 96.48 Very High Very High Very High
Arthritis 2 94.88 High High
Inflammatory Bowel Disease 2 94.32 High High
Cardiovascular Disease 2 93.48 High High
Toxicity 8 85.44 High High
Disease 126 75.00 Quite High
Autoimmune Disease 2 74.20 Quite High
Hemorrhage 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review focuses on developments with therapeutic relevance for inhibitors of LTA4H as anti-inflammatory drugs, and particularly in the treatment of respiratory disease.
Negative_regulation (inhibitors) of LTA4H in respiratory associated with inflammation, cinod and respiratory disease
1) Confidence 0.59 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19876785 Disease Relevance 1.07 Pain Relevance 0.34
For example, simultaneously inhibiting COX-2/1 and LTA4H, the [I]/Ki of COX-2 should be 400 to achieve effective treatment.
Negative_regulation (inhibiting) of LTA4H
2) Confidence 0.54 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.16 Pain Relevance 0.10
Several companies have initiated drug discovery efforts to identify potent, selective LTA4H inhibitors.
Negative_regulation (inhibitors) of LTA4H
3) Confidence 0.43 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19876785 Disease Relevance 0.93 Pain Relevance 0.33
In the case of simultaneously inhibiting PLA2, COX-2/1 and LTA4H, the value of [I]/Ki of COX-2 needed is reduced to 80.
Negative_regulation (inhibiting) of LTA4H
4) Confidence 0.39 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.17 Pain Relevance 0.09
The latter has utility in the measurement of the enzymatic and non-enzymatic transformations of LTA4 and in the characterisation of inhibitors of LTA4 epoxide hydrolase.
Negative_regulation (inhibitors) of LTA4
5) Confidence 0.26 Published 1986 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3012587 Disease Relevance 0 Pain Relevance 0.09

General Comments

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