INT33667

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Context Info
Confidence 0.72
First Reported 1986
Last Reported 2010
Negated 0
Speculated 8
Reported most in Abstract
Documents 15
Total Number 23
Disease Relevance 10.09
Pain Relevance 10.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
bladder 2
trigeminal ganglion 2
ovary 2
afferent neurons 2
sensory neurons 1
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 149 100.00 Very High Very High Very High
dorsal root ganglion 19 99.92 Very High Very High Very High
Inflammation 14 99.58 Very High Very High Very High
Spinal cord 10 99.08 Very High Very High Very High
trigeminal ganglion 24 99.00 Very High Very High Very High
Buprenorphine 4 98.28 Very High Very High Very High
agonist 6 97.98 Very High Very High Very High
opioid receptor 4 97.66 Very High Very High Very High
c fibre 18 97.64 Very High Very High Very High
Pain 23 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 69 99.92 Very High Very High Very High
Diabetes Mellitus 14 99.74 Very High Very High Very High
INFLAMMATION 10 99.58 Very High Very High Very High
Epilepsy 1 98.36 Very High Very High Very High
Diabetic Neuropathy 2 97.80 Very High Very High Very High
Pain 19 97.44 Very High Very High Very High
Nervous System Injury 3 97.36 Very High Very High Very High
Headache 24 96.00 Very High Very High Very High
Syndrome 1 87.48 High High
Neuropathic Pain 7 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CNGA2 and A3 proteins were found in cerebral arteries and dura and CNGA1, CNGA2 and CNGA3 in the trigeminal ganglion.
Gene_expression (found) of CNGA1 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.72 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.63 Pain Relevance 0.68
CONCLUSION: Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test.


Gene_expression (channels) of HCN in dorsal root ganglion
2) Confidence 0.59 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19322095 Disease Relevance 0 Pain Relevance 0
When the opioid receptor partial agonist, buprenorphine, was given systemically, immediately after CFA, the inflammation-induced increase in HCN protein expression in both Western blot and immunohistochemical experiments was not observed.
Gene_expression (expression) of HCN protein associated with inflammation, agonist, opioid receptor and buprenorphine
3) Confidence 0.54 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.58 Pain Relevance 1.32
HCN channels, particularly HCN1, are abundantly expressed in rat primary afferent somata.
Gene_expression (expressed) of HCN associated with hcn1
4) Confidence 0.52 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12598605 Disease Relevance 1.24 Pain Relevance 0.87
Alterations in HCN channel expression or function have been described in both epilepsy and cardiac arrhythmias.
Gene_expression (expression) of HCN associated with epilepsy
5) Confidence 0.51 Published 2004 Journal Pain Pract Section Abstract Doc Link 17173600 Disease Relevance 0.39 Pain Relevance 0.29
In conclusion, PDE3A, PDE3B, PDE5A, and five CNG subunits were expressed in several components of the trigeminovascular system of the rat.
Gene_expression (expressed) of CNG
6) Confidence 0.49 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.49 Pain Relevance 0.58
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Spec (determined) Gene_expression (expression) of CNG in basilar artery associated with ganglion cysts and trigeminal ganglion
7) Confidence 0.49 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
The major aim of the current study was to investigate altered HCN channel protein expression in trigeminal sensory neurons following inflammation of the dura.
Spec (investigate) Gene_expression (expression) of HCN in sensory neurons associated with inflammation
8) Confidence 0.47 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.53 Pain Relevance 0.63
Presumably, the channels are located on the more distal processes that are shorn off during the isolation procedure, an interpretation consistent with immunocytochemical findings that the HCN channel protein in the DCN is concentrated in the neuropil (Notomi & Shigemoto, 2004).
Gene_expression (concentrated) of HCN channel protein in neuropil
9) Confidence 0.43 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
HCN was produced from NaCN and H2SO4.
Gene_expression (produced) of HCN
10) Confidence 0.42 Published 1986 Journal Z. Rechtsmed. Section Abstract Doc Link 3012904 Disease Relevance 0.08 Pain Relevance 0.09
In dye-labeled bladder afferent neurons, HCN-2-positive cells were found in approximately 60% of neurons, and HCN-2 was expressed in both small- and medium-sized neurons with a higher ratio (expression ratio: 61% and 50% of neurons, respectively) compared with unidentified DRG neurons, in which the HCN expression ratio was 47% and 21% of small- and medium-sized cells, respectively.
Gene_expression (expression) of HCN in bladder associated with dorsal root ganglion
11) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16979600 Disease Relevance 0.48 Pain Relevance 0.70
Since hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel currents have been identified in various peripheral sensory neurons, we examined the expression of isoforms of HCN channels in the L6-S1 spinal cord and bladder afferent neurons from L6-S1 DRG in rats.
Spec (examined) Gene_expression (expression) of HCN in spinal cord associated with dorsal root ganglion and spinal cord
12) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16979600 Disease Relevance 0.49 Pain Relevance 0.55
HCN channels 1–3 are expressed in oocytes, granulosa cells of primary, preantral, and antral follicles, the thecal cells, and in luteal cells, while HCN4 is only expressed in oocytes.
Gene_expression (expressed) of HCN in follicles
13) Confidence 0.34 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.06
After electrophoresis, the proteins were electrically transferred to a nitrocellulose membrane (VWR International, West Chester, PA), blocked with 5% skim milk in TTBS (TBS with 0.1% Tween 20), and then incubated overnight at 4°C with rabbit polyclonal antibodies against HCN1-4 (anti-HCN 1, 2, 3 or 4; product # APC-056, APC-030, APC-057, APC-052, respectively; Alomone Labs Ltd., Jerusalem, Israel) [26] at a dilution of 1:200.
Gene_expression (product) of HCN associated with hcn1
14) Confidence 0.34 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.14
The expression of hyperpolarization activated cyclic nucleotide gated (HCN) channels in the rat ovary are dependent on the type of cell and the reproductive age of the animal: a laboratory investigation

Background

Spec (investigation) Gene_expression (expression) of HCN in ovary
15) Confidence 0.30 Published 2008 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2533335 Disease Relevance 0.06 Pain Relevance 0.19
All four HCN proteins were detected in ovaries of all three reproductive ages.
Gene_expression (detected) of HCN in ovaries
16) Confidence 0.30 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.43
These results indicate that diabetes induces the overexpression of HCN channels and the electrophysiological changes of HCN currents in the A- and C-fiber nodose neurons, which might contribute to the diabetes-induced alteration of cell excitability in the vagal afferent neurons.
Gene_expression (overexpression) of HCN in afferent neurons associated with c fibre and diabetes mellitus
17) Confidence 0.30 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.04 Pain Relevance 0.73
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the vagal afferent neurons and play an important role in determining cell membrane excitation.
Gene_expression (expressed) of HCN in afferent neurons
18) Confidence 0.30 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 0.67 Pain Relevance 0.26
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Spec (determined) Gene_expression (expression) of CNG in dura mater associated with ganglion cysts and trigeminal ganglion
19) Confidence 0.17 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Spec (determined) Gene_expression (expression) of CNG in middle cerebral artery associated with ganglion cysts and trigeminal ganglion
20) Confidence 0.17 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59

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