INT336690

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Vamp2) plasma membrane (Vamp2) protein complex assembly (Vamp2)
Anatomy Link Frequency
spinal cord neurons 2
vesicle 2
Vamp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 47 98.58 Very High Very High Very High
tetrodotoxin 15 95.44 Very High Very High Very High
Action potential 6 65.08 Quite High
Inflammation 3 44.32 Quite Low
withdrawal 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 95.92 Very High Very High Very High
Creutzfeldt Jakob Disease 12 68.12 Quite High
Lifespan 1 55.68 Quite High
Anaerobic Bacterial Infections 22 50.00 Quite Low
INFLAMMATION 3 44.32 Quite Low
Neurodegenerative Disease 15 14.88 Low Low
Disease Progression 3 13.76 Low Low
Wallerian Degeneration 15 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of proteins associated with the synaptic vesicle membrane were the first to show reduced levels of expression, including VAMP-2 (vesicle-associated membrane protein-2), synaptophysin and the chaperone CSP (cysteine string protein) (Gray et al., 2009), and these proteins were also reduced when compared with the levels of PSD-related proteins.
Negative_regulation (reduced) of Gene_expression (expression) of vesicle-associated membrane protein-2 in vesicle
1) Confidence 0.16 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.28 Pain Relevance 0
To test the physiological relevance of these observations, we monitored syb II levels in spinal cord neurons (Figure 2C) and observed that under high potassium conditions syb II immunofluorescence was reduced by 50% as compared to control and non-stimulating (i.e.
Negative_regulation (reduced) of Gene_expression (immunofluorescence) of syb II in spinal cord neurons associated with spinal cord
2) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.46

General Comments

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