INT336739

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.28
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (S100a8, Tlr4) cytoplasm (S100a8, Tlr4) signal transduction (Tlr4)
extracellular space (S100a8) extracellular region (S100a8) intracellular (Tlr4)
S100a8 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 96.44 Very High Very High Very High
Inflammatory response 6 58.84 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 97.56 Very High Very High Very High
INFLAMMATION 24 96.44 Very High Very High Very High
Targeted Disruption 41 95.72 Very High Very High Very High
Infection 31 82.72 Quite High
Urinary Tract Infection 42 76.88 Quite High
Bacterial Infection 1 60.08 Quite High
Sepsis 4 57.28 Quite High
Shock 1 42.64 Quite Low
Injury 1 37.00 Quite Low
Chronic Renal Failure 1 13.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, S100A8/A9 protein complex interacts with TLR4 [12] and the extent of S100A8/A9 expression correlates with disease activity in several inflammatory disorders [9], [10], [15], [16].
S100A8 Binding (interacts) of TLR4 associated with inflammation and disease
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.28 Pain Relevance 0.20

General Comments

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