INT336764

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2) plasma membrane (HLA-E)
Anatomy Link Frequency
B cells 2
ERAP2 (Homo sapiens)
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Eclampsia 6 5.00 Very Low Very Low Very Low
Malaria 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
ERAP2 Regulation (affects) of Gene_expression (presentation) of MHC in B cells
1) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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