INT336771

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.12
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2)
Anatomy Link Frequency
B cells 2
lymphocytes 1
ERAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 9 99.96 Very High Very High Very High
Inflammation 27 20.16 Low Low
spinal inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.78 Very High Very High Very High
Targeted Disruption 54 98.68 Very High Very High Very High
Lymphatic System Cancer 9 91.00 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 36 90.40 High High
Cancer 27 31.64 Quite Low
Eclampsia 54 11.12 Low Low
Malaria 36 5.00 Very Low Very Low Very Low
Reprotox - General 1 9 5.00 Very Low Very Low Very Low
Hypertension 9 5.00 Very Low Very Low Very Low
Low Back Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the above-described absence of detectable truncated ERAP2 protein may be due to NMD of Haplotype B-derived mRNA.
Negative_regulation (absence) of ERAP2
1) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Negative_regulation (deficiency) of ERAP2 in B cells
2) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
This result is consistent with the reduced MHC class I cell-surface expression observed after transient knock-down of ERAP1 or ERAP2 in cultured cells [48], the reduced MHC class I cell-surface expression seen in ERAP1-knock-out mice [54]–[56], [61], and our observation that ERAP1 is not upregulated to compensate for ERAP2 deficiency in cells from BB-homozygotes (Text S1).
Negative_regulation (deficiency) of ERAP2 associated with targeted disruption
3) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.42 Pain Relevance 0
To investigate the consequences of ERAP2 deficiency on MHC presentation, we correlated surface MHC class I expression with ERAP2 genotypes in primary lymphocytes.
Spec (investigate) Negative_regulation (deficiency) of ERAP2 in lymphocytes
4) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
This suggests that rather than affecting inflammatory response, ERAP2 deficiency might be relevant to basal MHC class I presentation.
Negative_regulation (deficiency) of ERAP2 associated with inflammatory response
5) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.42 Pain Relevance 0.05
In addition to these putative differences, we demonstrated that ERAP2 deficiency results in a quantitative reduction of MHC class I levels.
Negative_regulation (deficiency) of ERAP2
6) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.30 Pain Relevance 0
The absence of ERAP2 in the mouse genome precludes performing similar knock-out studies as with ERAP1, although one could envision a similar effect of ERAP2 deficiency in antigen presentation.
Negative_regulation (absence) of ERAP2 associated with targeted disruption
7) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.38 Pain Relevance 0
The absence of ERAP2 in the mouse genome precludes performing similar knock-out studies as with ERAP1, although one could envision a similar effect of ERAP2 deficiency in antigen presentation.
Negative_regulation (effect) of ERAP2 associated with targeted disruption
8) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.41 Pain Relevance 0
To establish whether endogenous ERAP2 deficiency has a similar effect in BB-homozygotes, we examined the levels of MHC class I molecules on the surface of peripheral blood B cells by flow cytometry.
Spec (whether) Negative_regulation (deficiency) of ERAP2 in B cells
9) Confidence 0.38 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0

General Comments

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