INT336772

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2)
Anatomy Link Frequency
reticulum 2
ERAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 17.52 Low Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
spinal inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 93.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 36 88.64 High High
Epstein-barr Virus 9 83.52 Quite High
Targeted Disruption 54 50.16 Quite High
INFLAMMATION 36 17.52 Low Low
Eclampsia 54 5.00 Very Low Very Low Very Low
Malaria 36 5.00 Very Low Very Low Very Low
Reprotox - General 1 9 5.00 Very Low Very Low Very Low
Hypertension 9 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, genetic analyses of six human populations revealed strong and consistent signatures of balancing selection affecting ERAP2.
Regulation (affecting) of ERAP2
1) Confidence 0.61 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Therefore, based on our results, the ERAP2 genotype should be accounted for in interpreting ERAP2 studies, especially those focused on ERAP2 expression and ERAP2 protein function.
Regulation (focused) of ERAP2
2) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0
These studies suggest that ERAP2 variants can alter splicing, raising the possibility of differences in the splicing of ERAP2 mRNA expressed from Haplotype A versus Haplotype B.
Regulation (alter) of ERAP2
3) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.08 Pain Relevance 0
A possible effect of ERAP2 deficiency could be an alteration in the set of peptides available for the MHC.
Spec (possible) Regulation (effect) of ERAP2
4) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.44 Pain Relevance 0
Effects of ERAP2 variants on mRNA processing and translation
Regulation (Effects) of ERAP2
5) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
In light of the differences in ERAP2 expression from the A versus B haplotypes, what are the biological consequences of lower ERAP2 protein levels in AB and BB individuals?
Regulation (consequences) of ERAP2
6) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.15 Pain Relevance 0
Effects of ERAP2 variants on mRNA splicing
Regulation (Effects) of ERAP2
7) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
In addition, we recently identified another key element of the MHC class I antigen-presentation process as a candidate target of balancing selection: endoplasmic reticulum aminopeptidase 2 (ERAP2) [3].
Regulation (target) of ERAP2 in reticulum
8) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
In addition, we recently identified another key element of the MHC class I antigen-presentation process as a candidate target of balancing selection: endoplasmic reticulum aminopeptidase 2 (ERAP2) [3].
Regulation (target) of aminopeptidase 2 in reticulum
9) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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