INT336775

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2)
ERAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
spinal inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 7 90.64 High High
Targeted Disruption 42 84.88 Quite High
Lymphatic System Cancer 7 72.80 Quite High
Eclampsia 42 5.00 Very Low Very Low Very Low
Malaria 28 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 28 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 21 5.00 Very Low Very Low Very Low
Reprotox - General 1 7 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three SNPs showed significantly lower levels of ERAP2 mRNA expressed from Haplotype B versus Haplotype A (Figure 5B) for all AB-heterozygote cell lines.
Transcription (levels) of ERAP2
1) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.14 Pain Relevance 0
Inhibition of NMD resulted in similar levels of ERAP2 mRNA expression from Haplotypes A and B (Figure 5B).
Transcription (expression) of ERAP2
2) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.14 Pain Relevance 0
These studies suggest that ERAP2 variants can alter splicing, raising the possibility of differences in the splicing of ERAP2 mRNA expressed from Haplotype A versus Haplotype B.
Transcription (expressed) of ERAP2
3) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0
The effect of rs2248374 on ERAP2 mRNA splicing was assessed using two in silico methods.
Transcription (splicing) of ERAP2
4) Confidence 0.69 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
These data indicate that NMD acts on Haplotype B-derived ERAP2 mRNA, accounting for both the reduced levels of Haplotype B-derived ERAP2 cDNA and the absence of truncated ERAP2 protein.


Transcription (derived) of ERAP2
5) Confidence 0.62 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.15 Pain Relevance 0
All three SNPs showed significantly lower levels of ERAP2 mRNA expressed from Haplotype B versus Haplotype A (Figure 5B) for all AB-heterozygote cell lines.
Transcription (expressed) of ERAP2
6) Confidence 0.53 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.14 Pain Relevance 0
The ERAP2 mRNA derived from Haplotype A encodes the canonical (full-length) ERAP2 protein consisting of 960 amino acids.
Transcription (derived) of ERAP2
7) Confidence 0.53 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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